Target General Infomation |
Target ID |
T51693
|
Former ID |
TTDR00750
|
Target Name |
Melanoma-associated antigen 3
|
Gene Name |
MAGEA3
|
Synonyms |
Antigen MZ2-D; MAGE-3 antigen; MAGE-A3; MAGE-A3 antigen; Melanoma antigen 3; Melanoma associated antigen-A3; MAGEA3
|
Target Type |
Clinical Trial
|
Function |
Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
|
BioChemical Class |
Melanoma associated antigen family
|
UniProt ID |
|
Sequence |
MPLEQRSQHCKPEEGLEARGEALGLVGAQAPATEEQEAASSSSTLVEVTLGEVPAAESPD PPQSPQGASSLPTTMNYPLWSQSYEDSSNQEEEGPSTFPDLESEFQAALSRKVAELVHFL LLKYRAREPVTKAEMLGSVVGNWQYFFPVIFSKASSSLQLVFGIELMEVDPIGHLYIFAT CLGLSYDGLLGDNQIMPKAGLLIIVLAIIAREGDCAPEEKIWEELSVLEVFEGREDSILG DPKKLLTQHFVQENYLEYRQVPGSDPACYEFLWGPRALVETSYVKVLHHMVKISGGPHIS YPPLHEWVLREGEE
|
Drugs and Mode of Action |
References |
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