Target Information
Target General Infomation | |||||
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Target ID |
T54472
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Former ID |
TTDR00299
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Target Name |
Cyclin-dependent protein kinase PfPK5
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Gene Name |
CRK2
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Synonyms |
Cell division control protein 2 homolog; CRK2
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Target Type |
Research
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Function |
Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity).
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BioChemical Class |
Kinase
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UniProt ID | |||||
EC Number |
EC 2.7.1.-
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Sequence |
MEKYHGLEKIGEGTYGVVYKAQNNYGETFALKKIRLEKEDEGIPSTTIREISILKELKHS
NIVKLYDVIHTKKRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDRR VLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKKYST TIDIWSVGCIFAEMVNGTPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDPNFTV YEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKENN |
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Inhibitor | Aminopurvalanol | Drug Info | [1] | ||
Indirubin-5-Sulphonate | Drug Info | [2] | |||
References | |||||
REF 1 | M-phase regulation of the recruitment of mRNAs onto polysomes using the CDK1/cyclin B inhibitor aminopurvalanol. Biochem Biophys Res Commun. 2003 Jul 11;306(4):880-6. | ||||
REF 2 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. |
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