Target Information
Target General Infomation | |||||
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Target ID |
T67942
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Former ID |
TTDR00871
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Target Name |
Cystathionine gamma-synthase
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Gene Name |
metB
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Synonyms |
CGS; O-succinylhomoserine (Thiol)-lyase; metB
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Target Type |
Research
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Function |
Catalyzes the formation of L-cystathionine from O- succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma- replacement reaction. In the absence of thiol, catalyzes gamma- elimination to form 2-oxobutanoate, succinate and ammonia.
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BioChemical Class |
Alkyl aryl transferase
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UniProt ID | |||||
EC Number |
EC 2.5.1.48
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Sequence |
MTRKQATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRA
LAELEGGAGAVLTNTGMSAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVL FVDQGDEQALRAALAEKPKLVLVESPSNPLLRVVDIAKICHLAREVGAVSVVDNTFLSPA LQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYL LLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAML SFELDGDEQTLRRFLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLL RISTGIEDGEDLIADLENGFRAANKG |
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References |
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