Target Information

Target General Infomation
Target ID
T68517
Former ID
TTDNR00685
Target Name
Heat shock protein 27
Gene Name
HSPB3
Synonyms
HSP 17; Heat shock 17 kDa protein; Heat shock protein beta3; HspB3; Protein 3; HSPB3
Target Type
Clinical Trial
Disease Atrial fibrillation [ICD9: 272, 427.31; ICD10: E78, I48]
Breast cancer; Ovarian cancer; Bladder cancer; Prostate cancer; Lung cancer [ICD9: 140-229, 162, 183, 188; ICD10: C00-C96, C33-C34, C56, C67]
Function
Inhibitor of actin polymerization.
BioChemical Class
Heat shock protein
UniProt ID
Q12988
Sequence
MAKIILRHLIEIPVRYQEEFEARGLEDCRLDHALYALPGPTIVDLRKTRAAQSPPVDSAA
ETPPREGKSHFQILLDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSFTRQYKL
PDGVEIKDLSAVLCHDGILVVEVKDPVGTK
Drugs and Mode of Action
Drug(s) OGX-427 Drug Info Phase 2 Breast cancer; Ovarian cancer; Bladder cancer; Prostate cancer; Lung cancer [525165]
NK-1001 Drug Info Discontinued in Phase 2 Atrial fibrillation [549188]
Modulator NK-1001 Drug Info [532907]
OGX-427 Drug Info [1572591]
References
Ref 525165ClinicalTrials.gov (NCT02423590) Study of Gemcitabine/Carboplatin First-line Chemotherapy +/- Apatorsen in Advanced Squamous Cell Lung Cancers. U.S. National Institutes of Health.
Ref 549188Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033456)
Ref
Ref 532907Novel therapeutic targets in the management of atrial fibrillation. Am J Cardiovasc Drugs. 2014 Dec;14(6):403-21.
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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