Target Information
Target General Infomation | |||||
---|---|---|---|---|---|
Target ID |
T77613
|
||||
Former ID |
TTDI02454
|
||||
Target Name |
Phosphodiesterase (PDE) 1B
|
||||
Gene Name |
PDE1B
|
||||
Synonyms |
63 kDa CamPDE; Calcium/calmodulindependent 3',5'cyclicnucleotide phosphodiesterase 1B; CamPDE 1B; PDE1B
|
||||
Target Type |
Research
|
||||
Disease | Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10: F01-F07, F04, F05, R41.3] | ||||
Function |
Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.
|
||||
BioChemical Class |
Phosphoric diester hydrolases
|
||||
UniProt ID | |||||
EC Number |
EC 3.1.4.17
|
||||
Sequence |
MELSPRSPPEMLEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEINIEELKKNL
EYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKP KFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHAL RTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLL RTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSV FRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPK ALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQS QIGFIDFIVEPTFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSLDVEVGDPNPDVVS FRSTWVKRIQENKQKWKERAASGITNQMSIDELSPCEEEAPPSPAEDEHNQNGNLD |
||||
Pathways | |||||
KEGG Pathway | Purine metabolism | ||||
Calcium signaling pathway | |||||
Morphine addiction | |||||
Reactome | cGMP effects | ||||
G alpha (s) signalling events | |||||
WikiPathways | G Protein Signaling Pathways | ||||
DAG and IP3 signaling | |||||
Opioid Signalling | |||||
References |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.