Target Information
| Target General Infomation | |||||
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| Target ID |
T77909
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| Former ID |
TTDR00236
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| Target Name |
Genome polyprotein
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| Synonyms |
Genome polyprotein; Protein VP1
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| Target Type |
Research
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| Function |
RNA-directed RNA polymerase: Replicates the viral genomic RNA on the surface of intracellular membranes. May form linear arrays of subunits that propagate along a strong head-to- tail interaction called interface-I.Covalently attaches UMP to a tyrosine of VPg, which is used to prime RNA synthesis. The positive stranded RNA genome is first replicated at virus induced membranous vesicles, creating a dsRNA genomicreplication form. This dsRNA is then used as template to synthesize positive stranded RNA genomes. ss(+)RNA genomes are either translated, replicated or encapsidated (By similarity).
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| UniProt ID | |||||
| Sequence |
MGAQVSRQNVGTHSTQNSVSNGSSLNYFNINYFKDAASSGASRLDFSQDPSKFTDPVKDV
LEKGIPTLQSPSVEACGYSDRIMQITRGDSTITSQDVANAVVGYGVWPHYLTPQDATAID KPTQPDTSSNRFYTLESKHWNGSSKGWWWKLPDALKDMGIFGENMYYHFLGRSGYTVHVQ CNASKFHQGTLLVAMIPEHQLASAKHGSVTAGYKLTHPGEAGRDVSQERDASLRQPSDDS WLNFDGTLLGNLLIFPHQFINLRSNNSATLIVPYVNAVPMDSMLRHNNWSLVIIPISPLR SETTSSNIVPITVSISPMCAEFSGARAKNIKQGLPVYITPGSGQFMTTDDMQSPCALPWY HPTKEISIPGEVKNLIEMCQVDTLIPVNNVGNNVGNVSMYTVQLGNQTGMAQKVFSIKVD ITSQPLATTLIGEIASYYTHWTGSLRFSFMFCGTANTTLKLLLAYTPPGIDEPTTRKDAM LGTHVVWDVGLQSTISLVVPWVSASHFRLTADNKYSMAGYITCWYQTNLVVPPSTPQTAD MLCFVSACKDFCLRMARDTDLHIQSGPIEQNPVENYIDEVLNEVLVVPNIKESHHTTSNS APLLDAAETGHTSNVQPEDAIETRYVITSQTRDEMSIESFLGRSGCVHISRIKVDYTDYN GQDINFTKWKITLQEMAQIRRKFELFTYVRFDSEITLVPCIAGRGDDIGHIVMQYMYVPP GAPIPSKRNDFSWQSGTNMSIFWQHGQPFPRFSLPFLSIASAYYMFYDGYDGDNTSSKYG SVVTNDMGTICSRIVTEKQKHSVVITTHIYHKAKHTKAWCPRPPRAVPYTHSHVTNYMPE TGDVTTAIVRRNTITTAGPSDLYVHVGNLIYRNLHLFNSEMHDSILISYSSDLIIYRTNT IGDDYIPNCNCTEATYYCRHKNRYYPIKVTPHDWYEIQESEYYPKHIQYNLLIGEGPCEP GDCGGKLLCRHGVIGIITAGGEGHVAFIDLRQFHCAEEQGITDYIHMLGEAFGNGFVDSV KEQINAINPINNISKKVIKWLLRIISAMVIIIRNSSDPQTIIATLTLIGCNGSPWRFLKE KFCKWTQLTYIHKESDSWLKKFTEMCNAARGLEWIGNKISKFIDWMKSMLPQAQLKVKYL NEIKKLSLLEKQIENLRAADSATQEKIKCEIDTLHDLSCKFLPLYAHEAKRIKVLYNKCS NIIKQRKRSEPVAVMIHGPPGTGKSITTNFLARMITNESDVYSLPPDPKYFDGYDNQSVV IMDDIMQNPDGEDMTLFCQMVSSVTFIPPMADLPDKGKPFDSRFILCSTNHSLLAPPTIS SLPAMNRRFFFDLDIVVHDNYKDTQGKLDVSKAFRPCNVNTKIGNAKCCPFVCGKAVXFK DRSTCSTYTLAQVYNHILEEDKRRRQVVDVMSAIFQGPISLDXPPPPAIXDLLQSVRTPE VIKYCQDNKWVIPAECQVERDLNIANSIIAIIANIISIAGIIFVIYKLFCSLQGPYSGEP KPKTKVPERRVVAQGPEEEFGRSILKNNTCVITTGNGKFTGLGIHDRILIIPTHADPGRE VQVNGVHTKVLDSYDLYNRDGVKLEITVIQLDRNEKFRDIRKYIPETEDDYPECNLALSA NQDEPTIIKVGDVVSYGNILLSGNQTARMLKYNYPTKSGYCGGVLYKIGQILGIHVGGNG RDGFSAMLLRSYFTDTQGQIKVNKHATECGLPTIHTPSKTKLQPSVFYDVFPGSKEPAVL TDNDPRLEVNFKEALFSKYKGNVECNLNEHMEIAIAHYSAQLMTLDIDSRPIALEDSVFG IEGLEALDLNTSAGFPYVTMGIKKRDLINNKTKDISRLKEALDKYGVDLPMITFLKDELR KKEKISTGKTRVIEASSINDTILFRTTFGNLFSKFHLNPGVVTGSAVGCDPETFWSKIPV MLDGDCIMAFDYTNYDGSIHPVWFQALKKVLENLSFQSNLIDRLCYSKHLFKSTYYEVAG GVPSGCSGTSIFNTMINNIIIRTLVLDAYKNIDLDKLKIIAYGDDVIFSYKYTLDMEAIA NEGKKYGLTITPADKSNEFKKLDYSNVTFLKRGFKQDERHTFLIHPTFPVEEIHESIRWT KKPSQMQEHVLSLCHLMWHNGRKVYEDFSSKIRSVSAGRALYIPPYDLLKHEWYEKF |
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| References | |||||
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