Target Information

Target General Infomation
Target ID
T79724
Former ID
TTDR00748
Target Name
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Gene Name
folK
Synonyms
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; 7,8- dihydro-6-hydroxymethylpterin-pyrophosphokinase; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK; PPPK; folK
Target Type
Research
BioChemical Class
Kinase
UniProt ID
P26281
EC Number
EC 2.7.6.3
Sequence
MTVAYIAIGSNLASPLEQVNAALKALGDIPESHILTVSSFYRTPPLGPQDQPDYLNAAVA
LETSLAPEELLNHTQRIELQQGRVRKAERWGPRTLDLDIMLFGNEVINTERLTVPHYDMK
NRGFMLWPLFEIAPELVFPDGEMLRQILHTRAFDKLNKW
Inhibitor 6-Hydroxymethyl-7,8-Dihydropterin Drug Info [551393]
6-Hydroxymethylpterin Drug Info [551391]
Acetate Ion Drug Info [551393]
Adenosine-5'-Diphosphate Drug Info [551391]
Alpha,Beta-Methyleneadenosine-5'-Triphosphate Drug Info [551393]
P(1)-(6-Hydroxymethylpterin)-P(2)-(5'-adenosyl)diphosphate Drug Info [535155]
P(1)-(6-Hydroxymethylpterin)-P(4)-(5'-adenosyl)tetraphosphate Drug Info [535155]
[Pterin-6-Yl Methanyl]-Phosphonophosphate Drug Info [551393]
References
Ref 535155Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: synthesis and biochemical and crystallographic studies. J Med Chem. 2001 Apr 26;44(9):1364-71.
Ref 551391DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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