Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T82913
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| Former ID |
TTDR00359
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| Target Name |
Elongation factor 1-alpha 1
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| Gene Name |
MEF-1
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| Synonyms |
EEF1A-1; EF-1-alpha-1; EF-Tu; Elongation factor 1 A-1; Elongation factor Tu; MEF-1
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| Target Type |
Clinical Trial
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| Disease | Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10: A00-B99] | ||||
| Function |
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
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| BioChemical Class |
Acid anhydrides hydrolase
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| UniProt ID | |||||
| EC Number |
EC 3.6.5.3
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| Sequence |
MGKEKTHINLVVIGHVDSGKSTTTGHIIYKLGGIDRRTIEKFEKESAEMGKGSFKYAWVL
DKLKAERERGITIDIALWKFETPRYFFTVIDAPGHKDFIKNMITGTSQADVALLVVPADV GGFDGAFSKEGQTKEHVLLAFTLGVKQIVVGVNKMDTVKYSEDRYEEIKKEVKDYLKKVG YQADKVDFIPISGFEGDNLIEKSDKTPWYKGRTLIEALDTMQPPKRPYDKPLRIPLQGVY KIGGIGTVPVGRVETGILKAGMVLNFAPSAVVSECKSVEMHKEVLEEARPGDNIGFNVKN VSVKEIKRGYVASDTKNEPAKGCSKFTAQVIILNHPGEIKNGYTPLLDCHTSHISCKFLN IDSKIDKRSGKVVEENPKAIKSGDSALVSLEPKKPMVVETFTEYPPLGRFAIRDMRQTIA VGIINQLKRKNLGAVTAKAPAKK |
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| Drugs and Mode of Action | |||||
| Drug(s) | Ge2270a | Drug Info | Phase 1 | Bacterial infections | [1] |
| Binder | Amythiamicin | Drug Info | [2] | ||
| Inhibitor | Ge2270a | Drug Info | [3] | ||
| Guanosine-5'-Diphosphate | Drug Info | [3] | |||
| References | |||||
| REF 1 | In vitro antimicrobial activity of a new antibiotic, MDL 62,879 (GE2270 A).. Antimicrob Agents Chemother. 1993 April; 37(4): 741-745. | ||||
| REF 2 | The apicoplast as an antimalarial drug target. Drug Resist Updat. 2001 Jun;4(3):145-51. | ||||
| REF 3 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
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