Target Information

Target General Infomation
Target ID
T86836
Former ID
TTDI01911
Target Name
Human DNA
Target Type
Successful
Disease Acute myeloid leukemia; Grade IV malignant glioma [ICD9:205, 191; ICD10: C92.0, C71]
Brain cancer [ICD9: 191, 225.0; ICD10: C71, D33]
Breast cancer [ICD9: 174, 175; ICD10: C50]
Colorectal cancer [ICD9: 153, 154; ICD10: C18-C21]
Cancer [ICD9: 140-229; ICD10: C00-C96]
Grade IV astrocytoma [ICD9: 191; ICD10: C71]
Gastric cancer [ICD9: 151; ICD10: C16]
Human immunodeficiency virus infection [ICD9: 279.3; ICD10: B20-B26]
Head and neck cancer [ICD9: 140-149, 140-229; ICD10: C07-C14, C32-C33]
Influenza A virus H5N1 [ICD9: 487, 488; ICD10: J10, J11]
Influenza A virus H1N1; Influenza A virus H5N1 [ICD9: 487, 488; ICD10: J10, J11]
Liver cancer [ICD9: 140-229, 155, 203.0; ICD10: C22]
Leukemia [ICD9: 208.9; ICD10: C90-C95]
Metastatic pancreatic [ICD10: C25.9]
Multiple myeloma [ICD9: 203; ICD10: C90]
Myeloproliferative disease [ICD9: 205.1, 238.4, 289.89, 289.9; ICD10: D47.1]
Malaria [ICD10: B54]
Myelodysplastic syndrome [ICD9: 238.7; ICD10: D46]
Mycobacterium tuberculosis infection [ICD10: A15-A19]
Non-invasive bladder cancer [ICD9: 188; ICD10: C67]
Ovarian cancer [ICD9: 183; ICD10: C56]
Prostate cancer [ICD9: 185; ICD10: C61]
Soft tissue sarcoma [ICD9: 171; ICD10: C00-D49]
Solid tumours [ICD9: 140-199, 210-229; ICD10: C00-D48]
Skin disease [ICD10: L00-L99]
Unspecified [ICD code not available]
Drugs and Mode of Action
Drug(s) Bendamustine hydrochloride Drug Info Approved Leukemia [529941]
Busulfan Drug Info Approved Myeloproliferative disease [538558], [542143]
Carboplatin Drug Info Approved Ovarian cancer [538307], [542611]
Carmustine Drug Info Approved Brain cancer [538486], [541883]
Cisplatin Drug Info Approved Cancer [536686], [540780]
Cyclophosphamide Drug Info Approved Cancer [536737], [542162]
Decitabine Drug Info Approved Myelodysplastic syndrome [528715], [541887], [551871]
DTI-015 Drug Info Approved Liver cancer [528163]
Ifosfamide Drug Info Approved Cancer [538310], [542215]
Melphalan Drug Info Approved Multiple myeloma [538468], [542608]
Oxaliplatin Drug Info Approved Colorectal cancer [537362], [542456]
Temozolomide Drug Info Approved Grade IV astrocytoma [536361], [542323]
Dicycloplatin Drug Info Registered Prostate cancer [549004]
Apaziquone Drug Info Phase 3 Non-invasive bladder cancer [544745]
Laromustine Drug Info Phase 3 Solid tumours [521645]
Lurbinectedin Drug Info Phase 3 Leukemia [525161]
Pafuramidine Drug Info Phase 3 Malaria [521811]
Taxol/Paraplatin/Herceptin Drug Info Phase 3 Breast cancer [528260]
13-DEOXYADRIAMYCIN HYDROCHLORIDE Drug Info Phase 2 Solid tumours [521653]
CGC-11047 Drug Info Phase 2 Prostate cancer [522195]
CO-101 Drug Info Phase 2 Metastatic pancreatic [523237]
CYSTEMUSTINE Drug Info Phase 2 Solid tumours [534654]
DM-CHOC-PEN Drug Info Phase 2 Brain cancer [548827]
FAD-104 Drug Info Phase 2 Solid tumours [544758]
JM216 Drug Info Phase 2 Solid tumours [525639]
LADIRUBICIN Drug Info Phase 2 Breast cancer [526474]
NDDP Drug Info Phase 2 Solid tumours [521458]
NHS-IL2-LT Drug Info Phase 2 Solid tumours [548550]
PM-00104 Drug Info Phase 2 Solid tumours [522662]
TETRAPLATIN TETRANITRATE Drug Info Phase 2 Cancer [521485]
TH-302 Drug Info Phase 2 Soft tissue sarcoma [523562], [543252]
TROXACITABINE Drug Info Phase 2 Solid tumours [521659]
BN-2629 Drug Info Phase 1/2 Solid tumours [524598]
GTU-TB vaccine Drug Info Phase 1/2 Mycobacterium tuberculosis infection [550660]
MBO7133 Drug Info Phase 1/2 Liver cancer [549973]
Melphalan flufenamide Drug Info Phase 1/2 Ovarian cancer [549220]
SECTA belomycin Drug Info Phase 1/2 Solid tumours [549907]
VAL-083 Drug Info Phase 1/2 Acute myeloid leukemia; Grade IV malignant glioma [523698]
5-FP Drug Info Phase 1 Solid tumours [530233]
BIZELESIN Drug Info Phase 1 Skin disease [521448]
DABIS MALEATE Drug Info Phase 1 Solid tumours [529022]
FFC-14A Drug Info Phase 1 Solid tumours [545763]
GALAMUSTINE HYDROCHLORIDE Drug Info Phase 1 Solid tumours [545215]
Gemcitabine prodrug Drug Info Phase 1 Cancer [523989], [531557]
INO-3401 Drug Info Phase 1 Influenza A virus H5N1 [523567]
INO-3510 Drug Info Phase 1 Influenza A virus H1N1; Influenza A virus H5N1 [523567]
LY-2334737 Drug Info Phase 1 Solid tumours [523989]
NC-4016 Drug Info Phase 1 Cancer [524551]
PENCLOMEDINE Drug Info Phase 1 Solid tumours [521446]
Pennvax-B Drug Info Phase 1 Human immunodeficiency virus infection [522468]
Pennvax-G Drug Info Phase 1 Human immunodeficiency virus infection [523292]
RH 1 Drug Info Phase 1 Unspecified [1560468]
T-0128 Drug Info Phase 1 Solid tumours [547247]
Thiarabine Drug Info Phase 1 Solid tumours [523065]
ARANOSE Drug Info Discontinued in Phase 3 Cancer [545706]
KW-2149 Drug Info Discontinued in Phase 3 Solid tumours [545214]
ADOZELESIN Drug Info Discontinued in Phase 2 Solid tumours [544754]
AP-5346 Drug Info Discontinued in Phase 2 Head and neck cancer [547589]
BBR-3438 Drug Info Discontinued in Phase 2 Gastric cancer [546285]
BISNAFIDE MESILATE Drug Info Discontinued in Phase 2 Solid tumours [545609]
CARZELESIN Drug Info Discontinued in Phase 2 Solid tumours [544949]
Glufosfamide Drug Info Discontinued in Phase 2 Ovarian cancer [536839]
NB-506 Drug Info Discontinued in Phase 2 Solid tumours [545864]
PIBROZELESIN HYDROCHLORIDE Drug Info Discontinued in Phase 2 Solid tumours [545397]
Tallimustine Drug Info Discontinued in Phase 2 Solid tumours [544837]
TOPIXANTRONE HYDROCHLORIDE Drug Info Discontinued in Phase 2 Gastric cancer [547312]
Clomet Drug Info Discontinued in Phase 1 Solid tumours [546923]
FK-973 Drug Info Discontinued in Phase 1 Solid tumours [544741]
PLD-147 Drug Info Discontinued in Phase 1 Solid tumours [547679]
RB-6145 Drug Info Discontinued in Phase 1 Solid tumours [545213]
S-23906-1 Drug Info Discontinued in Phase 1 Solid tumours [547429]
SR-271425 Drug Info Discontinued in Phase 1 Solid tumours [546998]
SW-33377 Drug Info Discontinued in Phase 1 Solid tumours [545413]
ZD-2767 Drug Info Discontinued in Phase 1 Solid tumours [545723]
BW-A502U Drug Info Terminated Solid tumours [545823]
Doxorubicin-CEA conjugate Drug Info Terminated Breast cancer [546274]
Modulator 13-DEOXYADRIAMYCIN HYDROCHLORIDE Drug Info [1572591]
Apaziquone Drug Info
Azathioprine Delayed-Release minitablets Drug Info
Bendamustine hydrochloride Drug Info [529941]
Busulfan Drug Info
Carboplatin Drug Info
Carmustine Drug Info [528163]
CGC-11047 Drug Info [530183]
Cisplatin Drug Info
Cyclophosphamide Drug Info
Decitabine Drug Info [528715]
DM-CHOC-PEN Drug Info [544086]
Doxorubicin-CEA conjugate Drug Info [556264]
doxorubicin-LL2 conjugate, Immunomedics Drug Info [1572605]
doxorubicin-peptide-PEG conjugate, Watson Drug Info [1572605]
Glufosfamide Drug Info
Ifosfamide Drug Info
JM216 Drug Info [1572591]
LY-2334737 Drug Info [532325]
Melphalan Drug Info
melphalan intravenous Drug Info [1572605]
NHS-IL2-LT Drug Info [1572591]
Oxaliplatin Drug Info
Pafuramidine Drug Info
PENCLOMEDINE Drug Info
PM-00104 Drug Info [531367]
RH 1 Drug Info
Tallimustine Drug Info
Temozolomide Drug Info [556264]
TH-302 Drug Info
VAL-083 Drug Info [533557]
Binder 5-FP Drug Info [526595]
ADOZELESIN Drug Info [533918]
AMBAZONE Drug Info [531681]
ARANOSE Drug Info [533415]
BBR-3438 Drug Info [526151]
BN-2629 Drug Info [544065]
BW-A502U Drug Info [533885]
CARZELESIN Drug Info [534807]
CYSTEMUSTINE Drug Info [529422]
DABIS MALEATE Drug Info [532452]
DTI-015 Drug Info [528163]
FAD-104 Drug Info [528401]
FFC-14A Drug Info [527657]
FK-973 Drug Info [531728]
KW-2149 Drug Info [534691]
LADIRUBICIN Drug Info [527651]
Laromustine Drug Info [530948]
MBO7133 Drug Info [550613]
Melphalan flufenamide Drug Info [550499]
NDDP Drug Info [533850]
PIBROZELESIN HYDROCHLORIDE Drug Info [529854]
PLD-147 Drug Info [530976]
RB-6145 Drug Info [544038]
S-23906-1 Drug Info [526206]
SECTA belomycin Drug Info [526886]
SR-271425 Drug Info [529950]
SW-33377 Drug Info [525510]
Taxol/Paraplatin/Herceptin Drug Info [528260]
TETRAPLATIN TETRANITRATE Drug Info [534053]
TROXACITABINE Drug Info [527096]
ZD-2767 Drug Info [544052]
Inhibitor AP-5346 Drug Info [528127]
BISNAFIDE MESILATE Drug Info [526841]
BIZELESIN Drug Info [533918]
Clomet Drug Info [528182]
CO-101 Drug Info [528281]
Dicycloplatin Drug Info [532616]
Gemcitabine prodrug Drug Info [528281]
Lurbinectedin Drug Info [532004]
NB-506 Drug Info [526318]
NC-4016 Drug Info [544448]
T-0128 Drug Info [525789]
Thiarabine Drug Info [544123]
TOPIXANTRONE HYDROCHLORIDE Drug Info [550571]
Antagonist GALAMUSTINE HYDROCHLORIDE Drug Info [533485]
References
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Ref 528163Carmustine-induced toxicity, DNA crosslinking and O6-methylguanine-DNA methyltransferase activity in two human lung cancer cell lines. Eur J Cancer. 1991;27(12):1658-62.
Ref 528182The comet assay: a sensitive genotoxicity test for the detection of DNA damage and repair. Methods Mol Biol. 2006;314:275-86.
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