Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T89054
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| Former ID |
TTDR00113
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| Target Name |
Adenylosuccinate synthetase
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| Gene Name |
Adss
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| Synonyms |
AMPSase; AdSS; Adenylosuccinate synthase; IMP--aspartate ligase; Adss
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| Target Type |
Clinical Trial
|
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| Function |
Plays an important role in the salvage pathway for purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
|
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| BioChemical Class |
Carbon-nitrogen ligase
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| UniProt ID | |||||
| EC Number |
EC 6.3.4.4
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| Sequence |
MNIFDHQIKNVDKGNVVAILGAQWGDEGKGKIIDMLSEYSDITCRFNGGANAGHTISVND
KKYALHLLPCGVLYDNNISVLGNGMVIHVKSLMEEIESVGGKLLDRLYLSNKAHILFDIH QIIDSIQETKKLKEGKQIGTTKRGIGPCYSTKASRIGIRLGTLKNFENFKNMYSKLIDHL MDLYNITEYDKEKELNLFYNYHIKLRDRIVDVISFMNTNLENNKKVLIEGANAAMLDIDF GTYPYVTSSCTTVGGVFSGLGIHHKKLNLVVGVVKSYLTRVGCGPFLTELNNDVGQYLRE KGHEYGTTTKRPRRCGWLDIPMLLYVKCINSIDMINLTKLDVLSGLEEILLCVNFKNKKT GELLEKGCYPVEEEISEEYEPVYEKFSGWKEDISTCNEFDELPENAKKYILAIEKYLKTP IVWIGVGPNRKNMIVKKNFNLN |
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| Drugs and Mode of Action | |||||
| Drug(s) | Alanosine | Drug Info | Phase 2 | Discovery agent | [1] |
| Inhibitor | (C8-R)-Hydantocidin 5'-Phosphate | Drug Info | [2] | ||
| (C8-S)-Hydantocidin 5'-Phosphate | Drug Info | [2] | |||
| (Carboxyhydroxyamino)Ethanoic Acid | Drug Info | [2] | |||
| 6-O-Phosphoryl Inosine Monophosphate | Drug Info | [2] | |||
| Alanosine | Drug Info | [3] | |||
| Beta-Mercaptoethanol | Drug Info | [2] | |||
| Diphosphate | Drug Info | [2] | |||
| Guanosine-5'-Diphosphate | Drug Info | [2] | |||
| Hadacidin | Drug Info | [4] | |||
| Hydantocidin-5'-Monophosphate | Drug Info | [2] | |||
| Hydantocidin-5'-Phosphate | Drug Info | [2] | |||
| Inosinic Acid | Drug Info | [2] | |||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT00062283) Alanosine in Treating Patients With Cancer. U.S. National Institutes of Health. | ||||
| REF 2 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
| REF 3 | Lack of methylthioadenosine phosphorylase expression in mantle cell lymphoma is associated with shorter survival: implications for a potential targeted therapy. Clin Cancer Res. 2006 Jun 15;12(12):3754-61. | ||||
| REF 4 | High performance liquid chromatography analysis of hypoxanthine metabolism in mouse oocyte-cumulus cell complexes: effects of purine metabolic perturbants. Biol Reprod. 1994 Jun;50(6):1403-12. | ||||
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