Target Information
Target General Infomation | |||||
---|---|---|---|---|---|
Target ID |
T95947
|
||||
Former ID |
TTDR01257
|
||||
Target Name |
Acid-sensing ion channel ASIC3
|
||||
Gene Name |
ASIC3
|
||||
Synonyms |
ACCN3; Acid-sensing ion channel 3; Amiloride-sensitive cation channel 3; Neuronal amiloride-sensitive cation channel 3; SLNAC1; TNAC1; Testis sodium channel 1; hASIC3; hTNaC1; ASIC3
|
||||
Target Type |
Research
|
||||
Disease | Fibromyalgia [ICD9: 729.1; ICD10: M79.7] | ||||
Pain [ICD9: 338, 356.0, 356.8,780; ICD10: G64, G90.0, R52, G89] | |||||
Function |
Cation channel with high affinity for sodium, whichis gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.
|
||||
BioChemical Class |
Amiloride-sensitive sodium channel
|
||||
UniProt ID | |||||
Sequence |
MKPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQV
AERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPA EHAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIF TRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQ IHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLG SPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLR KDSCACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNY ETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQR HSSTNLLQEGLGSHRTQVPHLSLGPRPPTPPCAVTKTLSASHRTCYLVTQL |
||||
Pathways | |||||
KEGG Pathway | Inflammatory mediator regulation of TRP channels | ||||
Reactome | Stimuli-sensing channels | ||||
WikiPathways | Iron uptake and transport | ||||
References |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.