Target Information
Target General Infomation | |||||
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Target ID |
T98179
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Former ID |
TTDR01018
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Target Name |
Phosphopantetheine adenylyltransferase
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Gene Name |
COASY
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Synonyms |
Dephospho-CoA pyrophosphorylase; PPAT; Pantetheine-phosphate adenylyltransferase; COASY
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Target Type |
Discontinued
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Disease | Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10: A00-B99] | ||||
Function |
Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation.
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BioChemical Class |
Kinase
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UniProt ID | |||||
EC Number |
EC 2.7.1.24
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Sequence |
VAGSPKQPVRGYYRGAVGGTFDRLHNAHKVLLSVACILAQEQLVVGVADKDLLKSKLLPE
LLQPYTERVEHLSEFLVDIKPSLTFDVIPLLDPYGPAGSDPSLEFLVVSEETYRGGMAIN RFRLENDLEELALYQIQLLKDLRHTENEEDKVSSSSFRQRMLGNLLRPPYERPELPTCL |
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Drugs and Mode of Action | |||||
Pathways | |||||
KEGG Pathway | Pantothenate and CoA biosynthesis | ||||
Metabolic pathways | |||||
WikiPathways | Metabolism of water-soluble vitamins and cofactors | ||||
References |
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