Target Information
Target General Infomation | |||||
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Target ID |
T98315
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Former ID |
TTDR01353
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Target Name |
mRNA of human acyl CoA cholesterol acyl-transferase-2
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Gene Name |
SOAT2
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Synonyms |
ACAT-2 (mRNA); Acyl-coenzyme A:cholesterol acyltransferase 2 (mRNA); Cholesterol acyltransferase 2 (mRNA); SOAT2 (mRNA); Sterol O-acyltransferase 2 (mRNA); SOAT2
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Target Type |
Research
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Function |
Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoproteinsecretion from hepatocytes and intestinal mucosa.
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BioChemical Class |
Acyltransferase
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Target Validation |
T98315
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UniProt ID | |||||
EC Number |
EC 2.3.1.26
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Sequence |
MEPGGARLRLQRTEGLGGERERQPCGDGNTETHRAPDLVQWTRHMEAVKAQLLEQAQGQL
RELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHF RTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLA PYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFL MKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKN FAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLH CWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARG VAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQRTGPAWNVLMWTM LFLGQGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT |
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Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
KEGG Pathway | Steroid biosynthesis | ||||
PANTHER Pathway | Androgen/estrogene/progesterone biosynthesis | ||||
References | |||||
Ref 527340 | Bioorg Med Chem Lett. 2005 Jan 17;15(2):385-8.Saucerneol B derivatives as human acyl-CoA: cholesterol acyltransferase inhibitors. |
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