Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| 5HT1a --- SERT | [2-(6-Chloro-1H-benzoimidazol-4-yloxy)-ethyl]-[3-(5-fluoro-1H-indol-3-yl)-propyl]-amine | Drug Info |
| 5HT1a --- SERT | WAY-100635 | Drug Info |
| 5HT1a --- SERT | (S)-1-(4-(4-methoxybenzo[b]thiophen-2-yl)piperidin-1-yl)-3-(2-methyl-1H-indol-4-yloxy)propan-2-ol | Drug Info |
| 5HT1b --- SERT | 3-(3,4-Dihydroxy-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester | Drug Info |
| 5LOX --- HRH1 | 1-{4-[4-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)phenyl]but-3-yn-1-yl}-1-hydroxyurea | Drug Info |
| ADRA1A --- HRH1 | 4-[(4-Chlorophenyl)methyl]-2-{2-[[4-(4-{[3-(hexahydro-1Hazepin-1-yl)propyl]oxy}phenyl)butyl](methyl)amino]ethyl}-1(2H)-phthalazinone | Drug Info |
| ADRA1A --- HRH1 | (R)-4-(3,4-Difluoro-phenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid {3-[4-cyano-4-(2,4-difluoro-phenyl)-piperidin-1-yl]-propyl}-amide | Drug Info |
| ADRA1A --- HRH1 | 4-[(4-Chlorophenyl)methyl]-2-(1-methylhexahydro-1H-azepin-3-yl)-1(2H)-phthalazinone | Drug Info |
| CABL --- Ckit | PHA848125 | Drug Info |
| CABL --- PI3K delta | PP121 | Drug Info |
| Aurora --- Chk | 1-[5-Chloro-2-(2-dimethylamino-1-methyl-ethoxy)-phenyl]-3-(5-cyano-pyrazin-2-yl)-urea | Drug Info |
| Aurora --- VEGFR | 7-(5-methoxy-1H-benzo[d]imidazol-2-yl)isoindolin-1-one | Drug Info |
| AuroraA --- STK1 | 2-Chloro-N-(4-(5-fluoro-2-(4-hydroxyphenylamino)pyrimidin-4-ylamino)phenyl)benzamide | Drug Info |
| AuroraA --- STK1 | CHEMBL214848 | Drug Info |
| AuroraA --- STK1 | [1-(3-{[4-({5-[(3-fluorobenzyl)thio]-1,3-thiazol-2-yl}amino)-6-methoxyquinazolin-7-yl]oxy}propyl)piperidin-4-yl]methanol | Drug Info |
| AuroraA --- STK1 | 2-(4-((5-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-ylamino)isothiazol-3-yl)methyl)piperazin-1-yl)ethanol | Drug Info |
| AuroraA --- STK1 | (2S,5R)-4-[2-Amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-5-methyl-N-phenyl-2-morpholinecarboxamide | Drug Info |
| AuroraA --- STK1 | N-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)-3-((4-methylpiperazin-1-yl)methyl)isothiazol-5-amine | Drug Info |
| AuroraA --- STK1 | 4-[3-(4-N-Phenylcarbamylaminophenyl)-1-ethyl-1H-pyrazol-4-yl]-2-[4-(N-morpholinylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridine | Drug Info |
| AuroraA --- STK1 | (+/-)-N-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)-3-(1-morpholinoethyl)isothiazol-5-amine | Drug Info |
| CDK1 --- Cyclin E | Olomoucine | Drug Info |
| Beta PDGFR --- Ckit | 4-[6-Methoxy-7-(3-piperidin-1-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (pyridin-4-ylmethyl)-amide | Drug Info |
| BNOS --- Hepatocyte NOS | 6-[7-(2-Dimethylamino-ethoxy)-indan-4-yl]-pyridin-2-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | 2-(2-(4-methoxypyridin-2-yl)ethyl)-6-phenyl-3H-imidazo[4,5-b]pyridine | Drug Info |
| BNOS --- Hepatocyte NOS | SID50104607 | Drug Info |
| BNOS --- Hepatocyte NOS | 2-Amino-5-(N-nitro-guanidino)-pentanoic acid | Drug Info |
| BNOS --- Hepatocyte NOS | [1,3]Oxazinan-(2E)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | 3-Methyl-[1,4]thiazepan-(5E)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | N-(5-chloro-2-nitrobenzyl)-N,1-dimethylpiperidin-4-amine | Drug Info |
| BNOS --- Hepatocyte NOS | 6-(4-(2-(dimethylamino)ethoxy)-5,6,7,8-tetrahydronaphthalen-1-yl)pyridin-2-amine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-Methyl-3,4-dihydro-1H-quinolin-(2E)-ylideneamine | Drug Info |
| CAI --- CAIX | 4-{4-[2-(1,4-oxazinan-4-yl)ethylamino(thioxo)methylamino]phenylsulfonamidomethyl}-1-benzenesulfonamide | Drug Info |
| 5HT1a --- SERT | (S)-1-(1H-indol-4-yloxy)-3-((2S,4R)-2-methyl-4-(4-methylbenzo[b]thiophen-2-yl)piperidin-1-yl)propan-2-ol | Drug Info |
| 5HT1a --- SERT | 6-((1-(2-(2-methylquinolin-5-yloxy)ethyl)piperidin-4-yl)methyl)-2H-benzo[b][1,4]oxazin-3(4H)-one | Drug Info |
| 5HT1a --- SERT | (S)-1-(1H-indol-4-yloxy)-3-((2S,4R)-4-(5-chlorobenzo[b]thiophen-2-yl)-2-methylpiperidin-1-yl)propan-2-ol | Drug Info |
| 5HT1b --- SERT | (R)-methyl 2-(4-chlorophenyl)-2-((R)-piperidin-2-yl)acetate | Drug Info |
| AChE --- NMDA | CHEMBL1198992 | Drug Info |
| ADRA1A --- HRH1 | 2-{[(2R)-1-Butyl-2-pyrrolidinyl]methyl}-4-[(4-chlorophenyl)methyl]-1(2H)-phthalazinone | Drug Info |
| ADRA1A --- HRH1 | Azelastine | Drug Info |
| ADRA1A --- HRH1 | 4-(3-(4-chlorophenyl)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl)-1-(4-fluorophenyl)butan-1-one | Drug Info |
| CABL --- Ckit | Bosutinib | Drug Info |
| CABL --- VEGFR1 | MK-2461 | Drug Info |
| Aurora --- GSK | 3-(3-phenyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-ylamino)isobenzofuran-1(3H)-one | Drug Info |
| AuroraA --- CDK4 | 7-bicyclo[2.2.1]heptan-2-yl-N-4-4-methylpiperazin-1-yl-phenyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine | Drug Info |
| AuroraA --- STK1 | N-(3-fluorophenyl)-2-(2-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]amino}-1,3-oxazol-5-yl)acetamide | Drug Info |
| AuroraA --- STK1 | N-[3-[(3(S)-Fluoro-1-pyrrolidinyl)methyl]-5-isothiazolyl]-6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Hydrochloride | Drug Info |
| AuroraA --- STK1 | ethyl 4-((5-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-ylamino)isothiazol-3-yl)methyl)piperazine-1-carboxylate | Drug Info |
| AuroraA --- STK1 | N-(4-{1-Ethyl-4-[2-({[2-(4-morpholinyl)ethyl]amino}methyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1H-pyrazol-3-yl}phenyl)-N'-phenylurea | Drug Info |
| AuroraA --- STK1 | 2,5,6,11-Tetrahydro-3-methylpyrazolo[4,3:6,7]cyclohepta[1,2-b]indole | Drug Info |
| AuroraA --- STK1 | 3-((4-(6-Bromo-2-(4-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo-[4,5-b]pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole | Drug Info |
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