Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| BNOS --- Hepatocyte NOS | 7-(2-Nitro-ethyl)-azepan-(2Z)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-(((3-chlorophenyl)(pyridin-3-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 4-(((2-chlorobenzyl)(pyrazin-2-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | (R)-2-(S)-Amino-3-methyl-5-(2-methyl-isothioureido)-pentanoic acid tert-butyl ester | Drug Info |
| BNOS --- Hepatocyte NOS | ((E)-7-But-2-enyl)-azepan-(2Z)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | trans rac-N1-(4-((6-amino-4-methylpyridin-2-yl)methyl)pyrrolidin-3-yl)-N2-(3-fluorophenethyl)ethane-1,2-diamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-Methyl-5,6,7,8-tetrahydro-quinolin-2-ylamine | Drug Info |
| 5HT1a --- SERT | 3-(4-(4-fluorophenyl)piperazin-1-yl)-1-phenylpropan-1-ol | Drug Info |
| 5HT1a --- SERT | 2-{1-[(S)-2-Hydroxy-3-(1H-indol-4-yloxy)-propyl]-piperidin-4-yl}-benzo[b]thiophen-7-ol | Drug Info |
| 5HT1a --- SERT | 2-((4-(5-fluoro-1H-indol-3-yl)-5,6-dihydropyridin-1(2H)-yl)methyl)-8-methoxy-4-propyl-3,4-dihydro-2H-benzo[b][1,4]oxazine | Drug Info |
| 5HT1b --- SERT | (S)-N-(2,3-dichlorobenzyl)-N-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-amine | Drug Info |
| A3AR --- ADRA1A | CHEMBL1625779 | Drug Info |
| ADRA1A --- HRH1 | cis-(-)-7,8-dimethoxy-3-[4-(2-methyl-3-(4-fluoro)phenyl-2(E)-propen-1-yl)piperazin-1-ylmethyl]-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazole | Drug Info |
| ADRA1A --- HRH1 | SID144207521 | Drug Info |
| ADRA1A --- HRH1 | N-(((cis)-4-(4-(dimethylamino)-5-methylpyrimidin-2-ylamino)cyclohexyl)methyl)-3,4-difluorobenzamide | Drug Info |
| CABL --- Ckit | AAL-993 | Drug Info |
| CABL --- STK1 | ENMD-2076 | Drug Info |
| Aurora --- GSK | 2-(2,6-dichlorophenylthio)-N-(5-methyl-1H-pyrazol-3-yl)quinazolin-4-amine | Drug Info |
| AuroraA --- ALK5 | 6-(3-Amino-1H-indazol-6-yl)-N4-methyl-2,4-pyrimidinediamine | Drug Info |
| AuroraA --- STK1 | N-(3-fluoro-4-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-ylamino)phenethyl)thieno[3,2-d]pyrimidin-4-amine | Drug Info |
| AuroraA --- STK1 | (+/-)-N-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)-3-(1-morpholinopropyl)isothiazol-5-amine | Drug Info |
| AuroraA --- STK1 | N-(4-(4-cyclopropyl-6-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylthio)phenyl)propionamide | Drug Info |
| AuroraA --- STK1 | N-[3-[(4,4-Difluoro-1-piperidinyl)methyl]-5-isothiazolyl]-6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Hydrochloride | Drug Info |
| AuroraA --- STK1 | N-(4-{4-[2-({[2-(Dimethylamino)ethyl]amino}methyl)-1Hpyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-1H-pyrazol-3-yl}phenyl)-N'-phenylurea | Drug Info |
| AuroraA --- STK1 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)-6-phenylpyrimidin-2-ylthio)phenyl)acetamide | Drug Info |
| AuroraA --- STK1 | (Z)-3-(4-Oxo-2-{[2-oxo-5-(piperidin-1-ylsulfonyl)indolin-3-ylidene]methyl}-4,5,6,7-tetrahydro-1H-indol-3-yl)propanoic Acid | Drug Info |
| AuroraA --- STK1 | N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-2-(phenylamino)benzamide | Drug Info |
| CDK1 --- CDK4 | Purvalanol A | Drug Info |
| Beta PDGFR --- CD135 | (1H-indol-2-yl)(5-methoxy-1H-indol-2-yl)methanone | Drug Info |
| BNOS --- Hepatocyte NOS | N-(3-Chlorophenyl)-N-((7,8-difluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)-4-methylthiazole-5-carboxamide | Drug Info |
| BNOS --- Hepatocyte NOS | 4-(((3-chlorophenyl)(1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | [1,3]Thiazinan-(2E)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-((benzyl(pyrazin-2-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 6-[4-(2-Dimethylamino-ethoxy)-naphthalen-1-yl]-pyridin-2-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-((2-(Cyclopentylmethyl)-1H-benzo[d]imidazol-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 2-Cyclobutyl-5-fluoro-1,2-dihydro-quinazolin-4-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | N-(3-Chlorophenyl)-N-((7,8-difluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)-4-methylnicotinamide | Drug Info |
| BNOS --- Hepatocyte NOS | Octahydro-isoindol-(1Z)-ylideneamine | Drug Info |
| CABL --- PKCA | N-(3-nitrophenyl)-4-(pyridin-2-yl)pyrimidin-2-amine | Drug Info |
| 5HT1a --- SERT | (S)-1-(1H-Indol-4-yloxy)-3-[(1R,3S,5S)-3-(4-methoxy-benzo[b]thiophen-2-yl)-8-aza-bicyclo[3.2.1]oct-8-yl]-propan-2-ol | Drug Info |
| 5HT1a --- SERT | (S)-1-(1H-indol-4-yloxy)-3-(4-(6-fluorobenzo[b]thiophen-2-yl)piperidin-1-yl)propan-2-ol | Drug Info |
| 5HT1a --- SERT | 3-(4-(2-chlorophenyl)piperazin-1-yl)-1-phenylpropan-1-ol | Drug Info |
| 5LOX --- HRH1 | [4-((2S,5S)-5-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-ylmethyl}-tetrahydro-furan-2-yl)-but-3-ynyl]-N-hydroxyurea | Drug Info |
| AChE --- NMDA | CHEMBL50608 | Drug Info |
| ADRA1A --- HRH1 | (8-methyl-5-(2-(6-methylpyridin-3-yl)ethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole | Drug Info |
| ADRA1A --- HRH1 | 3-{4-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carboxylic acid amide | Drug Info |
| ADRA1A --- HRH1 | SID170465934 | Drug Info |
| CABL --- FGFR1 | PHA848125 | Drug Info |
| CABL --- VEGFR1 | compound 8h | Drug Info |
| Aurora --- GSK | 4-(5-nitro-4-(phenylamino)pyrimidin-2-ylamino)benzoic acid | Drug Info |
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