Target Validation Information
Target ID T81900
Target Name Insulin-degrading Enzyme
Target Type
Successful
Drug Potency against Target Bacitracin Drug Info IC50 = 400000 nM [552714]
GNF-PF-4478 Drug Info IC50 = 10854 nM [531262]
References
Ref 552714Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE. J Biol Chem. 2007 Aug 31;282(35):25453-63. Epub 2007 Jul 5.
Ref 531262Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).

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