| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T92777 | ||||
| Target Name | Maltase-glucoamylase, intestinal | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | PONKORANOL | Drug Info | Ki = 170 nM | [531131] | |
| De-O-sulfonated kotalanol | Drug Info | Ki = 30 nM | [531230] | ||
| SALACINOL | Drug Info | Ki = 1000 nM | [531230] | ||
| KOTALANOL | Drug Info | Ki = 190 nM | [531230] | ||
| Deoxynojirimycin | Drug Info | IC50 = 4600 nM | [533823] | ||
| Acarbose | Drug Info | IC50 = 0.05 mM | |||
| 4'-(p-toluenesulfonamide)-3,4-dihydroxy chalcone | Drug Info | Ki = 240 nM | [527781] | ||
| 1,4-dideoxy-1,4-imino-D-arabinito | Drug Info | IC50 = 840 nM | [526274] | ||
| 2,5-Dideoxy-2,5-imino-D-mannitol | Drug Info | IC50 = 2000 nM | [526274] | ||
| References | |||||
| Ref 531131 | Bioorg Med Chem Lett. 2010 Oct 1;20(19):5686-9. Epub 2010 Aug 11.Probing the active-site requirements of human intestinal N-terminal maltase glucoamylase: the effect of replacing the sulfate moiety by a methyl ether in ponkoranol, a naturally occurring |A-glucosidase inhibitor. | ||||
| Ref 531230 | Bioorg Med Chem. 2010 Nov 15;18(22):7794-8. Epub 2010 Sep 29.Probing the active-site requirements of human intestinal N-terminal maltase-glucoamylase: Synthesis and enzyme inhibitory activities of asix-membered ring nitrogen analogue of kotalanol and its de-O-sulfonated derivative. | ||||
| Ref 531230 | Bioorg Med Chem. 2010 Nov 15;18(22):7794-8. Epub 2010 Sep 29.Probing the active-site requirements of human intestinal N-terminal maltase-glucoamylase: Synthesis and enzyme inhibitory activities of asix-membered ring nitrogen analogue of kotalanol and its de-O-sulfonated derivative. | ||||
| Ref 531230 | Bioorg Med Chem. 2010 Nov 15;18(22):7794-8. Epub 2010 Sep 29.Probing the active-site requirements of human intestinal N-terminal maltase-glucoamylase: Synthesis and enzyme inhibitory activities of asix-membered ring nitrogen analogue of kotalanol and its de-O-sulfonated derivative. | ||||
| Ref 533823 | J Med Chem. 1994 Oct 28;37(22):3701-6.Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. | ||||
| Ref 527781 | Bioorg Med Chem Lett. 2005 Dec 15;15(24):5514-6. Epub 2005 Oct 3.Sulfonamide chalcone as a new class of alpha-glucosidase inhibitors. | ||||
| Ref 526274 | J Nat Prod. 2002 Feb;65(2):198-202.New sugar-mimic alkaloids from the pods of Angylocalyx pynaertii. | ||||
| Ref 526274 | J Nat Prod. 2002 Feb;65(2):198-202.New sugar-mimic alkaloids from the pods of Angylocalyx pynaertii. | ||||
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