Drug General Information
Drug ID	D0S5LT
Former ID	DNC004647
Drug Name	Deoxynojirimycin
Drug Type	Small molecular drug
Indication	Pompe's disease [ICD10:E74.02]		Phase 3	[1]
Structure		Download 2D MOL 3D MOL
Formula	C6H13NO4
Canonical SMILES	C1C(C(C(C(N1)CO)O)O)O
InChI	1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
InChIKey	LXBIFEVIBLOUGU-JGWLITMVSA-N
PubChem Compound ID	29435
Target and Pathway
Target(s)	Maltase-glucoamylase, intestinal	Target Info	Inhibitor	[2]
	Alpha-glucosidase	Target Info	Inhibitor	[2]
	Lysosomal alpha-glucosidase	Target Info	Inhibitor	[3]
KEGG Pathway	Galactose metabolism
	Starch and sucrose metabolism
	Metabolic pathways
	Carbohydrate digestion and absorptionhsa00052:Galactose metabolism
	Lysosome
Pathway Interaction Database	Notch-mediated HES/HEY network
PathWhiz Pathway	Starch and Sucrose MetabolismPW000159:Galactose Metabolism
WikiPathways	Metabolism of carbohydrates
References
REF 1	The pharmacological chaperone 1-deoxynojirimycin increases the activity and lysosomal trafficking of multiple mutant forms of acid alpha-glucosidase. Hum Mutat. 2009 Dec;30(12):1683-92.
REF 2	J Med Chem. 1994 Oct 28;37(22):3701-6.Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases.
REF 3	Bioorg Med Chem. 2008 Aug 1;16(15):7330-6. Epub 2008 Jun 18.In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.