Drug General Information
Drug ID	D0S5LT
Former ID	DNC004647
Drug Name	Deoxynojirimycin
Drug Type	Small molecular drug
Indication	Pompe's disease [ICD10:E74.02]		Phase 3	[530482]
Structure		Download 2D MOL 3D MOL
Formula	C6H13NO4
Canonical SMILES	C1C(C(C(C(N1)CO)O)O)O
InChI	1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
InChIKey	LXBIFEVIBLOUGU-JGWLITMVSA-N
PubChem Compound ID	29435
Target and Pathway
Target(s)	Maltase-glucoamylase, intestinal	Target Info	Inhibitor	[533823]
	Alpha-glucosidase	Target Info	Inhibitor	[533823]
	Lysosomal alpha-glucosidase	Target Info	Inhibitor	[529573]
KEGG Pathway	Galactose metabolism
	Starch and sucrose metabolism
	Metabolic pathways
	Carbohydrate digestion and absorptionhsa00052:Galactose metabolism
	Lysosome
Pathway Interaction Database	Notch-mediated HES/HEY network
PathWhiz Pathway	Starch and Sucrose MetabolismPW000159:Galactose Metabolism
WikiPathways	Metabolism of carbohydrates
References
Ref 530482	The pharmacological chaperone 1-deoxynojirimycin increases the activity and lysosomal trafficking of multiple mutant forms of acid alpha-glucosidase. Hum Mutat. 2009 Dec;30(12):1683-92.
Ref 529573	Bioorg Med Chem. 2008 Aug 1;16(15):7330-6. Epub 2008 Jun 18.In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures.
Ref 533823	J Med Chem. 1994 Oct 28;37(22):3701-6.Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases.

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