Target Information

Target General Infomation
Target ID
T61339
Former ID
TTDR00001
Target Name
Alpha-glucosidase
Synonyms
Alpha-glucosidase
Target Type
Clinical Trial
Disease Cancer [ICD9: 140-229; ICD10: C00-C96]
Pompe's disease [ICD10: E74.02]
Unspecified [ICD code not available]
Target Validation
T61339
Drugs and Mode of Action
Drug(s) Deoxynojirimycin Drug Info Phase 3 Pompe's disease [530482]
Maltose Drug Info Phase 1/2 Discovery agent [523849]
Inhibitor 4,6-Dideoxyglucose Drug Info [551393]
6-Deoxy-Alpha-D-Glucose Drug Info [551393]
Beta-D-Glucose Drug Info [551393]
Deoxynojirimycin Drug Info [533823]
Double Oxidized Cysteine Drug Info [551393]
Maltose Drug Info [551391]
Nicotinamide-Adenine-Dinucleotide Drug Info [551393]
Tendamistat Drug Info [537965]
Modulator CS 1036 Drug Info
JBP-1 Drug Info [549592], [550162]
POP-1 Drug Info [549592], [550162]
References
Ref 523849ClinicalTrials.gov (NCT01562626) Phase I/II Study of APS001F With Flucytosine and Maltose in Solid Tumors. U.S. National Institutes of Health.
Ref 530482The pharmacological chaperone 1-deoxynojirimycin increases the activity and lysosomal trafficking of multiple mutant forms of acid alpha-glucosidase. Hum Mutat. 2009 Dec;30(12):1683-92.
Ref 533823J Med Chem. 1994 Oct 28;37(22):3701-6.Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases.
Ref 537965Influence of Specific Signal Peptide Mutations on the Expression and Secretion of the alpha -Amylase Inhibitor Tendamistat in Streptomyces lividans. J Biol Chem. 1996 Jun 21;271(25):15244-52.
Ref 549592US patent application no. 2012,0251,516, PHARMACEUTICAL COMPOSITION FOR TREATING CANCER COMPRISING TRYPSINOGEN AND/OR CHYMOTRYPSINOGEN AND AN ACTIVE AGENT SELECTED FROM A SELENIUM COMPOUND, A VANILLOID COMPOUND AND A CYTOPLASMIC GLYCOLYSIS REDUCTION AGENT.
Ref 550162EP patent application no. 2490711, A pharmaceutical composition for treating cancer comprising trypsinogen and/or chymotrypsinogen and an active agent selected from a selenium compound, a vanilloid compound and a cytoplasmic glycolysis reduction agent).
Ref 551391DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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