| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T24634 | ||||
| Target Name | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | EUPATORIOPICRIN | Drug Info | IC50 = 19800 nM | [528414] | |
| CYNAROPICRIN | Drug Info | IC50 = 12100 nM | [528414] | ||
| Fosfomycin | Drug Info | IC50 = 100 nM | [553067] | ||
| References | |||||
| Ref 528414 | Bioorg Med Chem Lett. 2006 Nov 1;16(21):5605-9. Epub 2006 Aug 30.Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA. | ||||
| Ref 528414 | Bioorg Med Chem Lett. 2006 Nov 1;16(21):5605-9. Epub 2006 Aug 30.Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA. | ||||
| Ref 553067 | Structure-activity relationships of tulipalines, tuliposides, and related compounds as inhibitors of MurA. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5757-62. doi: 10.1016/j.bmcl.2010.07.139. Epub 2010 Aug 5. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.