Target Validation Information | |||||
---|---|---|---|---|---|
Target ID | T76914 | ||||
Target Name | Potassium voltage-gated channel subfamily A member 3 | ||||
Target Type | Clinical Trial |
||||
Drug Potency against Target | 1-Benzyl-7-chloro-4-hexyloxy-quinolinium | Drug Info | IC50 = 828 nM | [533627] | |
Correloid | Drug Info | IC50 = 184 nM | [527342] | ||
4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one | Drug Info | IC50 = 740 nM | [531235] | ||
5-(4-Phenylbutoxy)psoralen | Drug Info | IC50 = 724 nM | [531233] | ||
2-Methoxy-N-(3-methyl-2-phenyl-butyl)-benzamide | Drug Info | IC50 = 150 nM | [526574] | ||
[1-Benzyl-1H-quinolin-(4E)-ylidene]-hexyl-amine | Drug Info | IC50 = 1053 nM | [533627] | ||
CP-339818 | Drug Info | IC50 = 230 nM | [526035] | ||
UK-78282 | Drug Info | IC50 = 280 nM | [526035] | ||
References | |||||
Ref 533627 | J Med Chem. 1995 May 26;38(11):1877-83.Novel inhibitors of potassium ion channels on human T lymphocytes. | ||||
Ref 527342 | Bioorg Med Chem Lett. 2005 Jan 17;15(2):447-51.Potent Kv1.3 inhibitors from correolide-modification of the C18 position. | ||||
Ref 531235 | Bioorg Med Chem Lett. 2010 Dec 1;20(23):6989-92. Epub 2010 Oct 23.Substituted N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs as potent Kv1.3 ion channel blockers. Part 2. | ||||
Ref 531233 | Bioorg Med Chem Lett. 2010 Dec 1;20(23):6983-8. Epub 2010 Oct 7.N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs as potent Kv1.3 inhibitors. Part 1. | ||||
Ref 526574 | Bioorg Med Chem Lett. 2003 Mar 24;13(6):1161-4.Benzamide derivatives as blockers of Kv1.3 ion channel. | ||||
Ref 533627 | J Med Chem. 1995 May 26;38(11):1877-83.Novel inhibitors of potassium ion channels on human T lymphocytes. | ||||
Ref 526035 | J Med Chem. 2001 Apr 12;44(8):1249-56.Angular methoxy-substituted furo- and pyranoquinolinones as blockers of the voltage-gated potassium channel Kv1.3. | ||||
Ref 526035 | J Med Chem. 2001 Apr 12;44(8):1249-56.Angular methoxy-substituted furo- and pyranoquinolinones as blockers of the voltage-gated potassium channel Kv1.3. |
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