Target Validation Information
Target ID T71390
Target Name 3-oxo-5-alpha-steroid 4-dehydrogenase 2
Target Type
Research
Drug Potency against Target 4-[4-benzyloxy)benzoyl]benzoic acid Drug Info IC50 = 119 nM [527979]
4,4'-dihydroxyoctafluoroazobenzene Drug Info IC50 = 790 nM [532449]
4-(4-phenoxybenzoyl)benzoic acid Drug Info IC50 = 53 nM [527979]
3-[4-(4-phenoxybenzoyl)phenyl]propanoic acid Drug Info IC50 = 2800 nM [527979]
2,3,5,6-Tetrafluoro-4-pentafluorophenylazo-phenol Drug Info IC50 = 2000 nM [532449]
ONO-3805 Drug Info IC50 = 2.6 nM [525525]
FK-143 Drug Info IC50 = 4.2 nM [525525]
References
Ref 527979J Med Chem. 2006 Jan 26;49(2):748-59.Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids.
Ref 532449J Med Chem. 1990 Sep;33(9):2452-5.Hydroxyperfluoroazobenzenes: novel inhibitors of enzymes of androgen biosynthesis.
Ref 527979J Med Chem. 2006 Jan 26;49(2):748-59.Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids.
Ref 527979J Med Chem. 2006 Jan 26;49(2):748-59.Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids.
Ref 532449J Med Chem. 1990 Sep;33(9):2452-5.Hydroxyperfluoroazobenzenes: novel inhibitors of enzymes of androgen biosynthesis.
Ref 525525Bioorg Med Chem Lett. 1999 Jun 7;9(11):1553-8.Dual-acting agents with alpha1-adrenoceptor antagonistic and steroid 5alpha-reductase inhibitory activities. Synthesis and evaluation of arylpiperazine derivatives.
Ref 525525Bioorg Med Chem Lett. 1999 Jun 7;9(11):1553-8.Dual-acting agents with alpha1-adrenoceptor antagonistic and steroid 5alpha-reductase inhibitory activities. Synthesis and evaluation of arylpiperazine derivatives.

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