| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T51565 | ||||
| Target Name | Casein kinase II, alpha chain | ||||
| Target Type | Discontinued |
||||
| Drug Potency against Target | 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole | Drug Info | IC50 = 13000 nM | [530101] | |
| APIGENIN | Drug Info | IC50 = 800 nM | [530101] | ||
| 4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole | Drug Info | IC50 = 900 nM | [530101] | ||
| 5,6,8-trichloroquinoline-4-one-3-carboxylic acid | Drug Info | IC50 = 300 nM | [528489] | ||
| EMODIN | Drug Info | IC50 = 2000 nM | [530101] | ||
| ELLAGIC ACID | Drug Info | IC50 = 40 nM | [530101] | ||
| 7,8-dichloroquinoline-4-one-3-carboxylic acid | Drug Info | IC50 = 800 nM | [528489] | ||
| 4,5,6,7-tetrabromo-1H-benzimidazole | Drug Info | IC50 = 1300 nM | [529933] | ||
| BALANOL | Drug Info | IC50 = 30 nM | [534297] | ||
| CGP-029482 | Drug Info | IC50 = 390 nM | [530101] | ||
| AdoC(Dpr)2AlaArg6 | Drug Info | IC50 = 17000 nM | [525511] | ||
| References | |||||
| Ref 530101 | Bioorg Med Chem Lett. 2009 Jun 1;19(11):2920-3. Epub 2009 Apr 22.Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid. | ||||
| Ref 530101 | Bioorg Med Chem Lett. 2009 Jun 1;19(11):2920-3. Epub 2009 Apr 22.Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid. | ||||
| Ref 530101 | Bioorg Med Chem Lett. 2009 Jun 1;19(11):2920-3. Epub 2009 Apr 22.Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid. | ||||
| Ref 528489 | J Med Chem. 2006 Nov 2;49(22):6443-50.Evaluation of 3-carboxy-4(1H)-quinolones as inhibitors of human protein kinase CK2. | ||||
| Ref 530101 | Bioorg Med Chem Lett. 2009 Jun 1;19(11):2920-3. Epub 2009 Apr 22.Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid. | ||||
| Ref 530101 | Bioorg Med Chem Lett. 2009 Jun 1;19(11):2920-3. Epub 2009 Apr 22.Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid. | ||||
| Ref 528489 | J Med Chem. 2006 Nov 2;49(22):6443-50.Evaluation of 3-carboxy-4(1H)-quinolones as inhibitors of human protein kinase CK2. | ||||
| Ref 529933 | Bioorg Med Chem. 2009 Feb 15;17(4):1573-8. Epub 2009 Jan 7.Synthesis of new analogs of benzotriazole, benzimidazole and phthalimide--potential inhibitors of human protein kinase CK2. | ||||
| Ref 534297 | J Med Chem. 1996 Dec 20;39(26):5215-27.Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A. | ||||
| Ref 530101 | Bioorg Med Chem Lett. 2009 Jun 1;19(11):2920-3. Epub 2009 Apr 22.Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid. | ||||
| Ref 525511 | Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. | ||||
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