Target Validation Information
Target ID T53764
Target Name Seprase
Target Type
Clinical Trial
Drug Potency against Target PF-00734200 Drug Info IC50 = 10300 nM [530008]
N-alkyl Gly-boro-Pro derivative Drug Info IC50 = 4.6 nM [527678]
References
Ref 530008Bioorg Med Chem Lett. 2009 Apr 1;19(7):1991-5. Epub 2009 Feb 13.(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor.
Ref 527678Bioorg Med Chem Lett. 2005 Oct 1;15(19):4239-42.Synthesis and structure-activity relationship of N-alkyl Gly-boro-Pro inhibitors of DPP4, FAP, and DPP7.

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