| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T71398 | ||||
| Target Name | Guanylate cyclase | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | Isosorbide Mononitrate | Drug Info | EC50 = 14.5 microM | [1] | |
| Isosorbide Dinitrate | Drug Info | EC50 = 0.28 mM | [1] | ||
| Action against Disease Model | Nitroglycerin | EC50 in Vasodilatory Effects in H uMan uMbilical Artery: 122nM | [2] | Drug Info | |
| References | |||||
| REF 1 | Structure-activity relationship of organic nitrates for activation of guanylate cyclase. Arch Int Pharmacodyn Ther. 1987 Dec;290(2):235-46. | ||||
| REF 2 | The vasodilatory effects of hydralazine, nicardipine, nitroglycerin, and fenoldopam in the human umbilical artery. Anesth Analg. 2003 Feb;96(2):539-44, table of contents. | ||||
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