Target Information

Target General Infomation
Target ID
T71398
Former ID
TTDS00443
Target Name
Guanylate cyclase
Synonyms
Guanylyl Cyclase
Target Type
Successful
Disease Angina pectoris; Anal fissure [ICD9: 413, 565.0; ICD10: I20, K60.0-K60.2]
Angina pectoris [ICD9: 413; ICD10: I20]
Cancer [ICD9: 140-229; ICD10: C00-C96]
Hydrocephalus; Glaucoma [ICD10: H40-H42]
Respiratory failure [ICD9: 518.81; ICD10: J96]
BioChemical Class
Phosphorus-oxygen lyases
Target Validation
T71398
Drugs and Mode of Action
Drug(s) Erythrityl Tetranitrate Drug Info Approved Angina pectoris [550675]
Isosorbide Dinitrate Drug Info Approved Angina pectoris; Anal fissure [538159], [542062]
Isosorbide Mononitrate Drug Info Approved Hydrocephalus; Glaucoma [551871]
Methylene blue Drug Info Approved Acquired methemoglobinemia [538085]
Nitric Oxide Drug Info Approved Respiratory failure [536500], [539631]
Nitric Oxide Drug Info Phase 3 Cancer [539631], [551871]
Pirsidomine Drug Info Phase 2 Angina pectoris [544801]
Stimulator Erythrityl Tetranitrate Drug Info [534837], [537618]
Isosorbide Dinitrate Drug Info [537452], [537618]
Isosorbide Mononitrate Drug Info [536948], [537618]
Nitric Oxide Drug Info [537618]
Inhibitor Methylene blue Drug Info [537384]
Modulator Pirsidomine Drug Info [534667]
References
Ref 536500Emerging therapies for treatment of acute lung injury and acute respiratory distress syndrome. Expert Opin Emerg Drugs. 2007 Sep;12(3):461-77.
Ref 538085Recombinant Plasmodium falciparum glutathione reductase is inhibited by the antimalarial dye methylene blue. FEBS Lett. 1998 Feb 6;422(3):311-4.
Ref 538159FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 040009.
Ref 539631(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2509).
Ref 542062(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7051).
Ref 544801Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001151)
Ref 550675Drug information of Erythrityl Tetranitrate, 2008. eduDrugs.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 534667Activation of soluble guanylyl cyclase by the nitrovasodilator 3-morpholinosydnonimine involves formation of S-nitrosoglutathione. Mol Pharmacol. 1998 Jul;54(1):207-12.
Ref 534837Nitric oxide modulation of the growth hormone-releasing activity of Hexarelin in young and old dogs. Metabolism. 1999 Feb;48(2):176-82.
Ref 536948Cervical priming in the first trimester: morphological and biochemical effects of misoprostol and isosorbide mononitrate. Acta Obstet Gynecol Scand. 2009;88(1):43-51.
Ref 537384Curcumin ameliorates high glucose-induced acute vascular endothelial dysfunction in rat thoracic aorta. Clin Exp Pharmacol Physiol. 2009 May 19.
Ref 537452No Recovery of Cold Complex Regional Pain Syndrome After Transdermal Isosorbide Dinitrate: A Small Controlled Trial. J Pain Symptom Manage. 2009 Jun 8.
Ref 537618Nitric oxide and nitric oxide synthase isoforms in the normal, hypertrophic, and failing heart. Mol Cell Biochem. 2009 Jul 19.

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