Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T71398
|
||||
| Former ID |
TTDS00443
|
||||
| Target Name |
Guanylate cyclase
|
||||
| Synonyms |
Guanylyl Cyclase
|
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| Target Type |
Successful
|
||||
| Disease | Angina pectoris; Anal fissure [ICD9: 413, 565.0; ICD10: I20, K60.0-K60.2] | ||||
| Angina pectoris [ICD9: 413; ICD10: I20] | |||||
| Cancer [ICD9: 140-229; ICD10: C00-C96] | |||||
| Hydrocephalus; Glaucoma [ICD10: H40-H42] | |||||
| Respiratory failure [ICD9: 518.81; ICD10: J96] | |||||
| BioChemical Class |
Phosphorus-oxygen lyases
|
||||
| Target Validation |
T71398
|
||||
| Drugs and Mode of Action | |||||
| Drug(s) | Erythrityl Tetranitrate | Drug Info | Approved | Angina pectoris | [1] |
| Isosorbide Dinitrate | Drug Info | Approved | Angina pectoris; Anal fissure | [2], [3] | |
| Isosorbide Mononitrate | Drug Info | Approved | Hydrocephalus; Glaucoma | [4] | |
| Methylene blue | Drug Info | Approved | Acquired methemoglobinemia | [5] | |
| Nitric Oxide | Drug Info | Approved | Respiratory failure | [6], [7] | |
| Nitric Oxide | Drug Info | Phase 3 | Cancer | [7], [4] | |
| Pirsidomine | Drug Info | Phase 2 | Angina pectoris | [8] | |
| Stimulator | Erythrityl Tetranitrate | Drug Info | [9], [10] | ||
| Isosorbide Dinitrate | Drug Info | [11], [10] | |||
| Isosorbide Mononitrate | Drug Info | [12], [10] | |||
| Nitric Oxide | Drug Info | [10] | |||
| Inhibitor | Methylene blue | Drug Info | [13] | ||
| Modulator | Pirsidomine | Drug Info | [14] | ||
| References | |||||
| REF 1 | Drug information of Erythrityl Tetranitrate, 2008. eduDrugs. | ||||
| REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 040009. | ||||
| REF 3 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7051). | ||||
| REF 4 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
| REF 5 | Recombinant Plasmodium falciparum glutathione reductase is inhibited by the antimalarial dye methylene blue. FEBS Lett. 1998 Feb 6;422(3):311-4. | ||||
| REF 6 | Emerging therapies for treatment of acute lung injury and acute respiratory distress syndrome. Expert Opin Emerg Drugs. 2007 Sep;12(3):461-77. | ||||
| REF 7 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2509). | ||||
| REF 8 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001151) | ||||
| REF 9 | Nitric oxide modulation of the growth hormone-releasing activity of Hexarelin in young and old dogs. Metabolism. 1999 Feb;48(2):176-82. | ||||
| REF 10 | Nitric oxide and nitric oxide synthase isoforms in the normal, hypertrophic, and failing heart. Mol Cell Biochem. 2009 Jul 19. | ||||
| REF 11 | No Recovery of Cold Complex Regional Pain Syndrome After Transdermal Isosorbide Dinitrate: A Small Controlled Trial. J Pain Symptom Manage. 2009 Jun 8. | ||||
| REF 12 | Cervical priming in the first trimester: morphological and biochemical effects of misoprostol and isosorbide mononitrate. Acta Obstet Gynecol Scand. 2009;88(1):43-51. | ||||
| REF 13 | Curcumin ameliorates high glucose-induced acute vascular endothelial dysfunction in rat thoracic aorta. Clin Exp Pharmacol Physiol. 2009 May 19. | ||||
| REF 14 | Activation of soluble guanylyl cyclase by the nitrovasodilator 3-morpholinosydnonimine involves formation of S-nitrosoglutathione. Mol Pharmacol. 1998 Jul;54(1):207-12. | ||||
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