| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T56556 | ||||
| Target Name | 5-aminoimidazole-4-carboxamidoribonucleotide (AICAR) transformylase | ||||
| Target Type | Successful |
||||
| Action against Disease Model | Sulfasalazine | Sulfasalazine induces apoptosis both in Jurkat cells, a h uMan T??leukaemia cell line (ED50 value ???1.0 mM), and in primary h uMan peripheral blood T??lymphocytes (ED50 value ???0.5 mM). In contrast SW620 colon carcinoma cells or primary h uMan synoviocytes are not affected at these concentrations suggesting a cell type??specific sensitivity to sulfasalazine. | [552311] | Drug Info | |
| References | |||||
| Ref 552311 | Molecular mechanisms of sulfasalazine-induced T-cell apoptosis. Br J Pharmacol. 2002 Nov;137(5):608-20. | ||||
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