Target Validation Information
Target ID T08813
Target Name CAMP-dependent protein kinase type I-alpha regulatory chain
Target Type
Research
Drug Potency against Target AdcAhxArg6 Drug Info IC50 = 700 nM [526704]
AdoC(betaAsp)2AlaArg6 Drug Info IC50 = 11100 nM [525511]
AdoC(GABA)Arg6 Drug Info IC50 = 1300 nM [525511]
AdcAhxArg4Lys(biotin)-PEG-OMe Drug Info IC50 = 1200 nM [526704]
AdoC(Aun)Arg6 Drug Info IC50 = 330 nM [525511]
5-(2-methylpiperazin-1-ylsulfonyl)isoquinoline Drug Info Ki = 3000 nM [534220]
RO-316233 Drug Info IC50 = 11800 nM [528701]
AdoCGlyArg6 Drug Info IC50 = 4000 nM [525511]
AdcAhxArg4Lys-PEGOMe Drug Info IC50 = 460 nM [526704]
AdoC(beta-Ala)Arg6 Drug Info IC50 = 1800 nM [525511]
AdoC(Dpr)2AlaArg6 Drug Info IC50 = 2600 nM [525511]
AdoC(beta-Ala)2AlaArg6 Drug Info IC50 = 4300 nM [525511]
AdoC(Aoc)Arg6 Drug Info IC50 = 240 nM [525511]
AdcAhxArg4NH(CH2)6NH2 Drug Info IC50 = 680 nM [526704]
AdoC(Ahx)Arg6 Drug Info IC50 = 120 nM [525511]
References
Ref 526704Bioorg Med Chem Lett. 2003 Sep 15;13(18):3035-9.Liquid-phase synthesis of a pegylated adenosine-oligoarginine conjugate, cell-permeable inhibitor of cAMP-dependent protein kinase.
Ref 525511Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases.
Ref 525511Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases.
Ref 526704Bioorg Med Chem Lett. 2003 Sep 15;13(18):3035-9.Liquid-phase synthesis of a pegylated adenosine-oligoarginine conjugate, cell-permeable inhibitor of cAMP-dependent protein kinase.
Ref 525511Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases.
Ref 534220J Biol Chem. 1996 Oct 18;271(42):26157-64.Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity.
Ref 528701J Med Chem. 1992 Jan;35(1):177-84.Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides.
Ref 525511Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases.
Ref 526704Bioorg Med Chem Lett. 2003 Sep 15;13(18):3035-9.Liquid-phase synthesis of a pegylated adenosine-oligoarginine conjugate, cell-permeable inhibitor of cAMP-dependent protein kinase.
Ref 525511Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases.
Ref 525511Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases.
Ref 525511Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases.
Ref 525511Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases.
Ref 526704Bioorg Med Chem Lett. 2003 Sep 15;13(18):3035-9.Liquid-phase synthesis of a pegylated adenosine-oligoarginine conjugate, cell-permeable inhibitor of cAMP-dependent protein kinase.
Ref 525511Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.