| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T69051 | ||||
| Target Name | PN3 Na+ channel | ||||
| Target Type | Research |
||||
| Drug Potency against Target | 5-(4-chlorophenyl)-N-(2-methylbenzyl)nicotinamide | Drug Info | IC50 = 9 nM | [1] | |
| N-(2-chlorobenzyl)-5-(4-chlorophenyl)nicotinamide | Drug Info | IC50 = 66 nM | [1] | ||
| N-benzyl-5-(4-chlorophenyl)nicotinamide | Drug Info | IC50 = 85 nM | [1] | ||
| 1-[5-(4-Chlorophenyl)-2-furoyl]piperazine | Drug Info | IC50 = 430 nM | [2] | ||
| References | |||||
| REF 1 | Bioorg Med Chem Lett. 2010 Nov 15;20(22):6812-5. Epub 2010 Sep 18.Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives. | ||||
| REF 2 | Bioorg Med Chem. 2008 Jun 15;16(12):6379-86. Epub 2008 May 6.Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain. | ||||
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