Target Validation Information
Target ID T98459
Target Name G2/mitotic-specific cyclin B1
Target Type
Research
Drug Potency against Target Thieno analogue of kenpaullone Drug Info IC50 = 600 nM [526916]
3,4-bis(indol-3-yl)maleimide derivative Drug Info IC50 = 4500 nM [534788]
AZAKENPAULLONE Drug Info IC50 = 2000 nM [526916]
KENPAULLONE Drug Info IC50 = 400 nM [531040]
GF-109203 Drug Info IC50 = 19000 nM [534788]
RO-316233 Drug Info IC50 = 18000 nM [534788]
References
Ref 526916Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6.1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta.
Ref 534788Bioorg Med Chem Lett. 1998 May 5;8(9):1019-22.Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure.
Ref 526916Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6.1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta.
Ref 531040Eur J Med Chem. 2010 Sep;45(9):4316-30. Epub 2010 Jun 30.Discovery of novel CDK1 inhibitors by combining pharmacophore modeling, QSAR analysis and in silico screening followed by in vitro bioassay.
Ref 534788Bioorg Med Chem Lett. 1998 May 5;8(9):1019-22.Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure.
Ref 534788Bioorg Med Chem Lett. 1998 May 5;8(9):1019-22.Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure.

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