Co-Target(s) Information
| Target General Information | Top | ||||
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| Target ID | T06093 | Target Info | |||
| Target Name | Rho-associated protein kinase 2 (ROCK2) | ||||
| Synonyms |
p164 ROCK-2; Rho-associated, coiled-coil-containing protein kinase II; Rho-associated, coiled-coil-containing protein kinase 2; Rho kinase 2; ROCK-II; KIAA0619
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| Target Type | Successful Target | ||||
| Gene Name | ROCK2 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Rho-associated protein kinase 1 (ROCK1) | Successful Target | ||||
| UniProt ID | ROCK1_HUMAN | |||||
| Gene Name | ROCK1 | |||||
| Synonyms |
Rok; Rho-associated, coiled-coil containing protein kinase 1; Rho-associated kinase 1; Rho kinase; ROCK1; ROCK; P160ROCK; P160(rock); P160 ROCK-1; Let-502 kinase
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| Representative Drug(s) | GSK269962A | Drug Info | IC50 = 1.6 nM | Click to Show More | [1] | |
| 2 | Belumosudil | Drug Info | Ki = 40 nM | [2] | ||
| Co-Target Name | RAC-alpha serine/threonine-protein kinase (AKT1) | Clinical trial Target | ||||
| UniProt ID | AKT1_HUMAN | |||||
| Gene Name | AKT1 | |||||
| Synonyms |
RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; PKB alpha
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| Representative Drug(s) | GSK269962A | Drug Info | IC50 = 955 nM | [3] | ||
| Co-Target Name | Ribosomal protein S6 kinase alpha-5 (RSK5) | Patented-recorded Target | ||||
| UniProt ID | KS6A5_HUMAN | |||||
| Gene Name | RPS6KA5 | |||||
| Synonyms |
S6K-alpha-5; RSKL; RSK-like protein kinase; Nuclear mitogen- and stress-activated protein kinase 1; MSK1; 90 kDa ribosomal protein S6 kinase 5
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| Representative Drug(s) | GSK269962A | Drug Info | IC50 = 49 nM | [3] | ||
| Co-Target Name | Ribosomal protein S6 kinase alpha-1 (RSK1) | Patented-recorded Target | ||||
| UniProt ID | KS6A1_HUMAN | |||||
| Gene Name | RPS6KA1 | |||||
| Synonyms |
p90S6K; p90RSK1; p90-RSK 1; S6K-alpha-1; Ribosomal S6 kinase 1; RSK-1; MAPKAPK1A; MAPKAPK-1a; MAPKAP kinase 1a; MAPK-activated protein kinase 1a; MAP kinase-activated protein kinase 1a; 90 kDa ribosomal protein S6 kinase 1
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| Representative Drug(s) | GSK269962A | Drug Info | IC50 = 132 nM | [3] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Potently inhibiting cancer cell migration with novel 3H-pyrazolo[4,3-f]quinoline boronic acid ROCK inhibitors. Eur J Med Chem. 2019 Oct 15;180:449-456. | ||||
| REF 2 | Fibrogenic Disorders in Human Diseases: From Inflammation to Organ Dysfunction. J Med Chem. 2018 Nov 21;61(22):9811-40. | ||||
| REF 3 | Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. J Pharmacol Exp Ther. 2007 Jan;320(1):89-98. | ||||
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