Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T16691 Target Info
Target Name 5-HT 6 receptor (HTR6)
Synonyms
Serotonin receptor 6; 5-hydroxytryptamine receptor 6; 5-HT6 receptor; 5-HT6; 5-HT-6
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Target Type Clinical trial Target
Gene Name HTR6
Biochemical Class GPCR rhodopsin
UniProt ID
5HT6R_HUMAN
Co-Targets of This Target  Top
Co-Target Name 5-HT 2A receptor (HTR2A) Successful Target
UniProt ID 5HT2A_HUMAN
Gene Name HTR2A
Synonyms
Serotonin receptor 2A; HTR2; 5-hydroxytryptamine receptor 2A; 5-HT-2A; 5-HT-2
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Representative Drug(s) SB-742457 Drug Info Ki = 26 nM Click to Show More [1]
2 LU AE58054 Drug Info Ki = 791 nM [3]
Co-Target Name 5-HT 2C receptor (HTR2C) Successful Target
UniProt ID 5HT2C_HUMAN
Gene Name HTR2C
Synonyms
Serotonin receptor 2C; HTR1C; 5HT-1C; 5-hydroxytryptamine receptor 2C; 5-hydroxytryptamine receptor 1C; 5-HTR2C; 5-HT2C receptor; 5-HT2C; 5-HT1C; 5-HT-2C; 5-HT-1C
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Representative Drug(s) LU AE58054 Drug Info Ki = 250 nM [2]
Co-Target Name Dopamine D2 receptor (D2R) Successful Target
UniProt ID DRD2_HUMAN
Gene Name DRD2
Synonyms
Dopamine receptor 2; D(2) dopamine receptor
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Representative Drug(s) SB-742457 Drug Info Ki = 997 nM [1]
References  Top
REF 1 Novel non-sulfonamide 5-HT6 receptor partial inverse agonist in a group of imidazo[4,5-b]pyridines with cognition enhancing properties. Eur J Med Chem. 2018 Jan 20;144:716-29.
REF 2 Novel aza-analogous ergoline derived scaffolds as potent serotonin 5-HT? and dopamine D? receptor ligands. J Med Chem. 2014 Jul 10;57(13):5823-8.
REF 3 Virtual screening-driven discovery of dual 5-HT 6/5-HT 2A receptor ligands with pro-cognitive properties. Eur J Med Chem. 2020 Jan 1;185:111857.

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