Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T20709 Target Info
Target Name Muscarinic acetylcholine receptor M4 (CHRM4)
Synonyms
M4 receptor; CHRM4
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Target Type Successful Target
Gene Name CHRM4
Biochemical Class GPCR rhodopsin
UniProt ID
ACM4_HUMAN
Co-Targets of This Target  Top
Co-Target Name Muscarinic acetylcholine receptor M3 (CHRM3) Successful Target
UniProt ID ACM3_HUMAN
Gene Name CHRM3
Synonyms
M3 receptor; CHRM3
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Representative Drug(s) Tropicamide Drug Info Ki = 30 nM Click to Show More [1]
2 Diphenidol Drug Info Ki = 52 nM [1]
Co-Target Name Muscarinic acetylcholine receptor M2 (CHRM2) Successful Target
UniProt ID ACM2_HUMAN
Gene Name CHRM2
Synonyms
M2 receptor; CHRM2
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Representative Drug(s) Tropicamide Drug Info Ki = 37 nM Click to Show More [1]
2 Diphenidol Drug Info Ki = 274 nM [1]
Co-Target Name Muscarinic acetylcholine receptor M5 (CHRM5) Successful Target
UniProt ID ACM5_HUMAN
Gene Name CHRM5
Synonyms
CHRM5
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Representative Drug(s) Tropicamide Drug Info Ki = 64 nM Click to Show More [1]
2 Diphenidol Drug Info Ki = 855 nM [1]
Co-Target Name Muscarinic acetylcholine receptor M1 (CHRM1) Successful Target
UniProt ID ACM1_HUMAN
Gene Name CHRM1
Synonyms
M1 receptor
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Representative Drug(s) Tropicamide Drug Info Ki = 68 nM Click to Show More [1]
2 Diphenidol Drug Info Ki = 78 nM [1]
Co-Target Name Opioid receptor sigma 1 (OPRS1) Successful Target
UniProt ID SGMR1_HUMAN
Gene Name SIGMAR1
Synonyms
hSigmaR1; Sigma1R; Sigma1-receptor; Sigma non-opioid intracellular receptor 1; Sigma 1-type opioid receptor; SRBP; SR31747-binding protein; SR31747 binding protein 1; SR-BP; SIG-1R; Opioid receptor, sigma 1, isoform 1; OPRS1 protein; Aging-associated gene 8 protein; AAG8
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Representative Drug(s) Diphenidol Drug Info Ki = 108 nM [1]
Co-Target Name Debrisoquine 4-hydroxylase (CYP2D6) Successful Target
UniProt ID CP2D6_HUMAN
Gene Name CYP2D6
Synonyms
P450-DB1; Cytochrome P450-DB1; Cytochrome P450 2D6; CYPIID6; CYP2DL1
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Representative Drug(s) Diphenidol Drug Info IC50 = 326.3 nM [1]
Co-Target Name 5-HT 2A receptor (HTR2A) Successful Target
UniProt ID 5HT2A_HUMAN
Gene Name HTR2A
Synonyms
Serotonin receptor 2A; HTR2; 5-hydroxytryptamine receptor 2A; 5-HT-2A; 5-HT-2
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Representative Drug(s) Diphenidol Drug Info Ki = 739 nM [1]
Co-Target Name Dopamine D3 receptor (D3R) Successful Target
UniProt ID DRD3_HUMAN
Gene Name DRD3
Synonyms
D(3) dopamine receptor
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Representative Drug(s) Diphenidol Drug Info Ki = 785 nM [1]
Co-Target Name S-mephenytoin 4-hydroxylase (CYP2C9) Successful Target
UniProt ID CP2C9_HUMAN
Gene Name CYP2C9
Synonyms
Cytochrome P450 PB-1; Cytochrome P450 MP-8; Cytochrome P450 MP-4; Cytochrome P450 2C9; Cytochrome P-450MP; Cholesterol 25-hydroxylase; CYPIIC9; CYP2C10; (S)-limonene 7-monooxygenase; (S)-limonene 6-monooxygenase; (R)-limonene 6-monooxygenase
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Representative Drug(s) Tropicamide Drug Info IC50 = 1000 nM [1]
Co-Target Name Cytochrome P450 2C19 (CYP2C19) Co-Target
UniProt ID CP2CJ_HUMAN
Gene Name CYP2C19
Synonyms
Fenbendazole monooxygenase (4'-hydroxylating); (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
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Representative Drug(s) Tropicamide Drug Info IC50 = 1000 nM [1]
References  Top
REF 1 DrugMatrix in vitro pharmacology data. National Toxicology Program

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