Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T24983 Target Info
Target Name Dopamine D4 receptor (D4R)
Synonyms
DRD4; D(2C)D(4) dopamine receptor dopamine receptor
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Target Type Successful Target
Gene Name DRD4
Biochemical Class GPCR rhodopsin
UniProt ID
DRD4_HUMAN
Co-Targets of This Target  Top
Co-Target Name Muscarinic acetylcholine receptor M1 (CHRM1) Successful Target
UniProt ID ACM1_HUMAN
Gene Name CHRM1
Synonyms
M1 receptor
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Representative Drug(s) Clozapine Drug Info Ki = 0.98 nM [1]
Co-Target Name Histamine H1 receptor (H1R) Successful Target
UniProt ID HRH1_HUMAN
Gene Name HRH1
Synonyms
HH1R; H1R
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Representative Drug(s) Clozapine Drug Info Ki = 1 nM [2]
Co-Target Name 5-HT 2A receptor (HTR2A) Successful Target
UniProt ID 5HT2A_HUMAN
Gene Name HTR2A
Synonyms
Serotonin receptor 2A; HTR2; 5-hydroxytryptamine receptor 2A; 5-HT-2A; 5-HT-2
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Representative Drug(s) Clozapine Drug Info Ki = 2.692 nM Click to Show More [3]
2 L-745,870 Drug Info Ki = 200 nM [13]
Co-Target Name 5-HT 2C receptor (HTR2C) Successful Target
UniProt ID 5HT2C_HUMAN
Gene Name HTR2C
Synonyms
Serotonin receptor 2C; HTR1C; 5HT-1C; 5-hydroxytryptamine receptor 2C; 5-hydroxytryptamine receptor 1C; 5-HTR2C; 5-HT2C receptor; 5-HT2C; 5-HT1C; 5-HT-2C; 5-HT-1C
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Representative Drug(s) Clozapine Drug Info Ki = 2.884 nM [4]
Co-Target Name Adrenergic receptor alpha-2C (ADRA2C) Successful Target
UniProt ID ADA2C_HUMAN
Gene Name ADRA2C
Synonyms
Subtype C4; Alpha-2CAR; Alpha-2C adrenoreceptor; Alpha-2C adrenoceptor; Alpha-2C adrenergic receptor; Alpha-2 adrenergic receptor subtype C4; ADRA2RL2; ADRA2L2
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Representative Drug(s) Clozapine Drug Info Ki = 2.9 nM Click to Show More [5]
2 L-745,870 Drug Info Ki = 230 nM [13]
Co-Target Name 5-HT 2B receptor (HTR2B) Successful Target
UniProt ID 5HT2B_HUMAN
Gene Name HTR2B
Synonyms
Serotonin receptor 2B; 5-hydroxytryptamine receptor 2B; 5-HT2B; 5-HT-2B; 5-HT 2B
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Representative Drug(s) Clozapine Drug Info Ki = 3.162 nM [6]
Co-Target Name 5-HT 2 receptor (5HT2R) Successful Target
UniProt ID 5HT2A_HUMAN; 5HT2B_HUMAN; 5HT2C_HUMAN
Gene Name NO-GeName
Synonyms
Serotonin receptor 2; 5-hydroxytryptamine receptor 2; 5-HT2 receptor
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Representative Drug(s) Clozapine Drug Info Ki = 5.012 nM Click to Show More [7]
2 L-745,870 Drug Info Ki = 200 nM [1]
Co-Target Name 5-HT 1A receptor (HTR1A) Successful Target
UniProt ID 5HT1A_HUMAN
Gene Name HTR1A
Synonyms
Serotonin receptor 1A; G-21; ADRBRL1; ADRB2RL1; 5-hydroxytryptamine receptor 1A; 5-HT1A receptor; 5-HT1A; 5-HT-1A
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Representative Drug(s) Clozapine Drug Info Ki = 6.38 nM Click to Show More [4]
2 NGD 94-1 Drug Info Ki = 180 nM [13]
Co-Target Name Dopamine D2 receptor (D2R) Successful Target
UniProt ID DRD2_HUMAN
Gene Name DRD2
Synonyms
Dopamine receptor 2; D(2) dopamine receptor
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Representative Drug(s) Clozapine Drug Info Ki = 7.11 nM Click to Show More [4]
2 L-745,870 Drug Info Ki = 448 nM [18]
Co-Target Name Dopamine D1 receptor (D1R) Successful Target
UniProt ID DRD1_HUMAN
Gene Name DRD1
Synonyms
D(1A) dopamine receptor
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Representative Drug(s) Clozapine Drug Info Ki = 7.5 nM Click to Show More [4]
2 Phenyltoloxamine Drug Info Ki = 343 nM [16]
Co-Target Name Cyclin-dependent kinase 4 (CDK4) Successful Target
UniProt ID CDK4_HUMAN
Gene Name CDK4
Synonyms
PSK-J3; Cell division protein kinase 4
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Representative Drug(s) Palbociclib Drug Info IC50 = 9 nM [8]
Co-Target Name Adrenergic receptor alpha-1B (ADRA1B) Successful Target
UniProt ID ADA1B_HUMAN
Gene Name ADRA1B
Synonyms
Alpha-1B adrenoreceptor; Alpha-1B adrenoceptor; Alpha-1B adrenergic receptor; Alpha 1B-adrenoreceptor; Alpha 1B-adrenoceptor
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Representative Drug(s) Clozapine Drug Info Ki = 10 nM [9]
Co-Target Name Adrenergic receptor alpha-1A (ADRA1A) Successful Target
UniProt ID ADA1A_HUMAN
Gene Name ADRA1A
Synonyms
Alpha-adrenergic receptor 1c; Alpha-1C adrenergic receptor; Alpha-1A adrenoreceptor; Alpha-1A adrenoceptor; Alpha-1A adrenergic receptor; Alpha adrenergic receptor 1c; Alpha 1A-adrenoreceptor; Alpha 1A-adrenoceptor; ADRA1C
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Representative Drug(s) Clozapine Drug Info Ki = 10 nM [9]
Co-Target Name Muscarinic acetylcholine receptor M4 (CHRM4) Successful Target
UniProt ID ACM4_HUMAN
Gene Name CHRM4
Synonyms
M4 receptor; CHRM4
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Representative Drug(s) Clozapine Drug Info Ki = 12.59 nM [6]
Co-Target Name Cyclin-dependent kinase 6 (CDK6) Successful Target
UniProt ID CDK6_HUMAN
Gene Name CDK6
Synonyms
Serine/threonine-protein kinase PLSTIRE; Serine/threonine protein kinase PLSTIRE; Cell division protein kinase 6; CDKN6
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Representative Drug(s) Palbociclib Drug Info IC50 = 15 nM [8]
Co-Target Name Adrenergic receptor alpha-2A (ADRA2A) Successful Target
UniProt ID ADA2A_HUMAN
Gene Name ADRA2A
Synonyms
Alpha-2AAR; Alpha-2A adrenoreceptor; Alpha-2A adrenoceptor; Alpha-2A adrenergic receptor; Alpha-2 adrenergic receptor subtype C10; ADRAR; ADRA2R
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Representative Drug(s) Clozapine Drug Info Ki = 24 nM Click to Show More [5]
2 L-745,870 Drug Info Ki = 170 nM [13]
Co-Target Name Muscarinic acetylcholine receptor (CHRM) Successful Target
UniProt ID ACM1_HUMAN; ACM2_HUMAN; ACM3_HUMAN; ACM4_HUMAN; ACM5_HUMAN
Gene Name NO-GeName
Representative Drug(s) Clozapine Drug Info Ki = 34 nM [10]
Co-Target Name Adrenergic receptor Alpha-2 (ADRA2) Successful Target
UniProt ID ADA2A_HUMAN; ADA2B_HUMAN; ADA2C_HUMAN
Gene Name NO-GeName
Synonyms
Alpha-2 adrenergic receptor; Alpha(2)-adrenoceptor
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Representative Drug(s) Clozapine Drug Info Ki = 51 nM Click to Show More [1]
2 Clozapine Drug Info Ki = 51 nM [1]
Co-Target Name Janus kinase 3 (JAK-3) Successful Target
UniProt ID JAK3_HUMAN
Gene Name JAK3
Synonyms
Tyrosine-protein kinase JAK3; Leukocyte janus kinase; L-JAK
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Representative Drug(s) Palbociclib Drug Info IC50 = 63.1 nM [11]
Co-Target Name Dopamine D3 receptor (D3R) Successful Target
UniProt ID DRD3_HUMAN
Gene Name DRD3
Synonyms
D(3) dopamine receptor
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Representative Drug(s) Clozapine Drug Info Ki = 88 nM Click to Show More [12]
2 L-745,870 Drug Info Ki = 380.19 nM [17]
Co-Target Name Adrenergic receptor alpha-2B (ADRA2B) Successful Target
UniProt ID ADA2B_HUMAN
Gene Name ADRA2B
Synonyms
Subtype C2; Alpha-2BAR; Alpha-2B adrenoreceptor; Alpha-2B adrenoceptor; Alpha-2B adrenergic receptor; Alpha-2 adrenergic receptor subtype C2; ADRA2RL1; ADRA2L1
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Representative Drug(s) Clozapine Drug Info Ki = 100 nM Click to Show More [9]
2 L-745,870 Drug Info Ki = 160 nM [13]
Co-Target Name Muscarinic acetylcholine receptor M2 (CHRM2) Successful Target
UniProt ID ACM2_HUMAN
Gene Name CHRM2
Synonyms
M2 receptor; CHRM2
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Representative Drug(s) Clozapine Drug Info Ki = 100 nM [9]
Co-Target Name Muscarinic acetylcholine receptor M3 (CHRM3) Successful Target
UniProt ID ACM3_HUMAN
Gene Name CHRM3
Synonyms
M3 receptor; CHRM3
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Representative Drug(s) Clozapine Drug Info Ki = 100 nM [9]
Co-Target Name Muscarinic acetylcholine receptor M5 (CHRM5) Successful Target
UniProt ID ACM5_HUMAN
Gene Name CHRM5
Synonyms
CHRM5
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Representative Drug(s) Clozapine Drug Info Ki = 100 nM [9]
Co-Target Name Opioid receptor sigma 1 (OPRS1) Successful Target
UniProt ID SGMR1_HUMAN
Gene Name SIGMAR1
Synonyms
hSigmaR1; Sigma1R; Sigma1-receptor; Sigma non-opioid intracellular receptor 1; Sigma 1-type opioid receptor; SRBP; SR31747-binding protein; SR31747 binding protein 1; SR-BP; SIG-1R; Opioid receptor, sigma 1, isoform 1; OPRS1 protein; Aging-associated gene 8 protein; AAG8
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Representative Drug(s) L-745,870 Drug Info Ki = 130 nM [1]
Co-Target Name 5-HT 3A receptor (HTR3A) Successful Target
UniProt ID 5HT3A_HUMAN
Gene Name HTR3A
Synonyms
Serotonin-gated ion channel receptor; Serotonin receptor 3A; HTR3; 5HT3R; 5-hydroxytryptamine receptor 3A; 5-HT3RA; 5-HT3A; 5-HT3-A; 5-HT 3A
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Representative Drug(s) Clozapine Drug Info Ki = 186.21 nM Click to Show More [3]
2 NGD 94-1 Drug Info Ki = 750 nM [13]
Co-Target Name Voltage-gated potassium channel Kv11.1 (KCNH2) Successful Target
UniProt ID KCNH2_HUMAN
Gene Name KCNH2
Synonyms
hERG1; hERG-1; Voltage-gated potassium channel subunit Kv11.1; Potassium voltage-gated channel subfamily H member 2; HERG K+ channel; HERG; H-ERG; Ether-a-go-go-related protein 1; Ether-a-go-go-related gene potassium channel 1; Ether-a-go-go related protein 1; Ether-a-go-go related gene potassium channel 1; Eag related protein 1; Eag homolog; ERG-1; ERG
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Representative Drug(s) Clozapine Drug Info IC50 = 190.55 nM [14]
Co-Target Name Dopamine D5 receptor (D5R) Successful Target
UniProt ID DRD5_HUMAN
Gene Name DRD5
Synonyms
Dopamine receptor 5; DRD5; D1beta dopamine receptor; D(5)D(1B) dopamine receptor dopamine receptor; D(5) dopamine receptor
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Representative Drug(s) Clozapine Drug Info Ki = 198 nM Click to Show More [15]
2 Phenyltoloxamine Drug Info Ki = 414 nM [16]
Co-Target Name 5-HT 3 receptor (5HT3R) Successful Target
UniProt ID 5HT3A_HUMAN; 5HT3B_HUMAN; 5HT3C_HUMAN; 5HT3D_HUMAN; 5HT3E_HUMAN
Gene Name NO-GeName
Synonyms
5-hydroxytryptamine receptor type 3; 5-hydroxytryptamine receptor 3; 5-HT3R; 5-HT3 receptor; 5-HT-3
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Representative Drug(s) Clozapine Drug Info Ki = 398.11 nM [6]
Co-Target Name 5-HT 1B receptor (HTR1B) Successful Target
UniProt ID 5HT1B_HUMAN
Gene Name HTR1B
Synonyms
Serotonin receptor 1B; Serotonin 1D beta receptor; S12; HTR1DB; 5-hydroxytryptamine receptor 1B; 5-HT1B receptor; 5-HT1B; 5-HT-1D-beta; 5-HT-1B
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Representative Drug(s) Clozapine Drug Info Ki = 1000 nM [9]
Co-Target Name 5-HT 1D receptor (HTR1D) Successful Target
UniProt ID 5HT1D_HUMAN
Gene Name HTR1D
Synonyms
Serotonin receptor 1D; Serotonin 1D alpha receptor; HTRL; HTR1DA; 5HT1D; 5-hydroxytryptamine receptor 1D; 5-HT1D receptor; 5-HT1D; 5-HT-1D-alpha; 5-HT-1D
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Representative Drug(s) Clozapine Drug Info Ki ~ 1000 nM [9]
Co-Target Name 5-HT 1E receptor (HTR1E) Successful Target
UniProt ID 5HT1E_HUMAN
Gene Name HTR1E
Synonyms
Serotonin receptor 1E; S31; 5-hydroxytryptamine receptor 1E; 5-HT1E; 5-HT-1E; 5-HT 1E
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Representative Drug(s) Clozapine Drug Info Ki = 1000 nM [9]
Co-Target Name 5-HT 5A receptor (HTR5A) Successful Target
UniProt ID 5HT5A_HUMAN
Gene Name HTR5A
Synonyms
Serotonin receptor 5A; 5-hydroxytryptamine receptor 5A; 5-HT5A; 5-HT-5A; 5-HT-5; 5-HT 5A
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Representative Drug(s) Clozapine Drug Info Ki = 1000 nM [19]
Co-Target Name 5-HT 6 receptor (HTR6) Clinical trial Target
UniProt ID 5HT6R_HUMAN
Gene Name HTR6
Synonyms
Serotonin receptor 6; 5-hydroxytryptamine receptor 6; 5-HT6 receptor; 5-HT6; 5-HT-6
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Representative Drug(s) Clozapine Drug Info Ki = 4 nM [20]
Co-Target Name 5-HT 7 receptor (HTR7) Clinical trial Target
UniProt ID 5HT7R_HUMAN
Gene Name HTR7
Synonyms
Serotonin receptor 7; 5HT7; 5-hydroxytryptamine receptor 7; 5-HT7 receptor; 5-HT7; 5-HT-X; 5-HT-7
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Representative Drug(s) Clozapine Drug Info Ki = 5.5 nM Click to Show More [21]
2 L-745,870 Drug Info Ki = 226.3 nM [23]
Co-Target Name Histamine H4 receptor (H4R) Clinical trial Target
UniProt ID HRH4_HUMAN
Gene Name HRH4
Synonyms
SP9144; Pfi-013; HH4R; H4 receptor; GPRv53; GPCR105; G protein-coupled receptor 105; AXOR35
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Representative Drug(s) Clozapine Drug Info Ki = 177.83 nM [22]
Co-Target Name Positive transcription elongation factor b (P-TEFb) Clinical trial Target
UniProt ID CDK9_HUMAN-CCNT1_HUMAN
Gene Name CDK9-CCNT1
Synonyms
P-TEFb
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Representative Drug(s) Palbociclib Drug Info Ki = 364 nM [24]
Co-Target Name Histamine H3 receptor (H3R) Clinical trial Target
UniProt ID HRH3_HUMAN
Gene Name HRH3
Synonyms
Histamine receptor 3; HH3R; GPCR97; G-protein coupled receptor 97; G protein-coupled receptor 97
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Representative Drug(s) Clozapine Drug Info Ki = 631 nM [25]
Co-Target Name Cyclin-dependent kinase 9 (CDK9) Clinical trial Target
UniProt ID CDK9_HUMAN
Gene Name CDK9
Synonyms
Tat-associated kinase complex catalytic subunit; TAK; Similar to cyclin-dependent kinase 9; Serine/threonine-protein kinase PITALRE; Cyclin-dependent protein kinase Cdk9; Cell division protein kinase 9; Cell division cycle 2-like protein kinase 4; CDC2L4; CDC2-related kinase; C-2K
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Representative Drug(s) Palbociclib Drug Info IC50 = 794.33 nM [11]
Co-Target Name HUAMN alpha-1 adrenergic receptor (ADRA1) Literature-reported Target
UniProt ID ADA1A_HUMAN; ADA1B_HUMAN; ADA1D_HUMAN
Gene Name ADRA1A; ADRA1B; ADRA1D
Synonyms
Alpha-1 adrenoreceptor
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Representative Drug(s) Clozapine Drug Info Ki = 3.7 nM [1]
Co-Target Name Cyclin dependent kinase 4-G1/S specific cyclin D1 complex (CDK4-CCND1) Co-Target
UniProt ID CDK4_HUMAN-CCND1_HUMAN
Gene Name CDK4-CCND1
Representative Drug(s) Palbociclib Drug Info IC50 = 2 nM [26]
Co-Target Name Cyclin dependent kinase 6-G1/S specific cyclin D1 complex (CDK6-CCND1) Co-Target
UniProt ID CDK6_HUMAN-CCND1_HUMAN
Gene Name CDK6-CCND1
Representative Drug(s) Palbociclib Drug Info IC50 = 3.76 nM [27]
Co-Target Name Cyclin dependent kinase 6-G1/S specific cyclin D2 complex (CDK6-CCND2) Co-Target
UniProt ID CDK6_HUMAN-CCND2_HUMAN
Gene Name CDK6-CCND2
Representative Drug(s) Palbociclib Drug Info IC50 = 9 nM [28]
Co-Target Name Cyclin dependent kinase 4-G1/S specific cyclin D complex (CDK4-CCND) Co-Target
UniProt ID CDK4_HUMAN-CCND1_HUMAN/CCND2_HUMAN/CCND3_HUMAN
Gene Name CDK4-CCND1-CCND2/CCND3
Representative Drug(s) Palbociclib Drug Info IC50 = 11 nM [29]
Co-Target Name Cyclin dependent kinase 6-G1/S specific cyclin D3 complex (CDK6-CCND2) Co-Target
UniProt ID CDK6_HUMAN-CCND3_HUMAN
Gene Name CDK6-CCND3
Representative Drug(s) Palbociclib Drug Info IC50 = 19 nM [30]
Co-Target Name Cyclin dependent kinase 2-Cyclin A2 complex (CDK2-CCNA2) Co-Target
UniProt ID CDK2_HUMAN-CCNA2_HUMAN
Gene Name CDK2-CCNA2
Representative Drug(s) Palbociclib Drug Info IC50 = 230 nM [27]
References  Top
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REF 2 Discovery of a tetracyclic quinoxaline derivative as a potent and orally active multifunctional drug candidate for the treatment of neuropsychiatric and neurological disorders. J Med Chem. 2014 Mar 27;57(6):2670-82.
REF 3 Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4263-6.
REF 4 Action of benzimidazolo-piperazinyl derivatives on dopamine receptors. Med Chem Res. 2012 Apr 24;22:520-30.
REF 5 Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents. J Med Chem. 2005 Mar 24;48(6):1709-12.
REF 6 Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs. J Med Chem. 2007 Oct 18;50(21):5103-8.
REF 7 Pharmacological evaluation of a diarylmethylene-piperidine derivative: a new potent atypical antipsychotic?. Bioorg Med Chem Lett. 2001 May 21;11(10):1313-6.
REF 8 Third-generation CDK inhibitors: A review on the synthesis and binding modes of Palbociclib, Ribociclib and Abemaciclib. Eur J Med Chem. 2019 Jun 15;172:143-153.
REF 9 The synthesis and receptor binding affinities of DDD-016, a novel, potential, atypical antipsychotic. Medchemcomm. 2012;3:580-3.
REF 10 Selective optimization of side activities: another way for drug discovery. J Med Chem. 2004 Mar 11;47(6):1303-14.
REF 11 Selectivity data: assessment, predictions, concordance, and implications. J Med Chem. 2013 Sep 12;56(17):6991-7002.
REF 12 Molecular modeling of the three-dimensional structure of dopamine 3 (D3) subtype receptor: discovery of novel and potent D3 ligands through a hybri... J Med Chem. 2003 Oct 9;46(21):4377-92.
REF 13 Return of D 4 Dopamine Receptor Antagonists in Drug Discovery. J Med Chem. 2017 Sep 14;60(17):7233-7243.
REF 14 GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers. Eur J Med Chem. 2009 May;44(5):1926-32.
REF 15 Potential utility of histamine H3 receptor antagonist pharmacophore in antipsychotics. Bioorg Med Chem Lett. 2009 Jan 15;19(2):538-42.
REF 16 Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 ... J Med Chem. 2004 Aug 12;47(17):4155-8.
REF 17 1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) as a Model for the Rational Design of a Novel Class of Brain Penetrant Ligands with High Affinity and Selectivity for Dopamine D. J Med Chem. 2018 Apr 26;61(8):3712-25.
REF 18 Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning. J Med Chem. 2004 Apr 22;47(9):2348-55.
REF 19 Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7). J Med Chem. 2003 Jul 3;46(14):2795-812.
REF 20 Novel multi-target azinesulfonamides of cyclic amine derivatives as potential antipsychotics with pro-social and pro-cognitive effects. Eur J Med Chem. 2018 Feb 10;145:790-804.
REF 21 The synthesis and comparative receptor binding affinities of novel, isomeric pyridoindolobenzazepine scaffolds. Bioorg Med Chem Lett. 2014 Jan 15;24(2):576-9.
REF 22 Characterization of the histamine H4 receptor binding site. Part 1. Synthesis and pharmacological evaluation of dibenzodiazepine derivatives. J Med Chem. 2006 Jul 27;49(15):4512-6.
REF 23 Synthesis of potent and selective dopamine D(4) antagonists as candidate radioligands. Bioorg Med Chem Lett. 2001 Jun 4;11(11):1375-7.
REF 24 Highly Potent, Selective, and Orally Bioavailable 4-Thiazol-N-(pyridin-2-yl)pyrimidin-2-amine Cyclin-Dependent Kinases 4 and 6 Inhibitors as Anticancer Drug Candidates: Design, Synthesis, and Evaluation. J Med Chem. 2017 Mar 9;60(5):1892-915.
REF 25 2-(4-alkylpiperazin-1-yl)quinolines as a new class of imidazole-free histamine H3 receptor antagonists. J Med Chem. 2005 Jan 13;48(1):306-11.
REF 26 Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3. J Med Chem. 2014 Apr 24;57(8):3430-49.
REF 27 Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5). J Med Chem. 2014 Feb 13;57(3):578-99.
REF 28 Cyclin dependent kinase (CDK) inhibitors as anticancer drugs. Bioorg Med Chem Lett. 2015 Sep 1;25(17):3420-35.
REF 29 Discovery of a potent and selective inhibitor of cyclin-dependent kinase 4/6. J Med Chem. 2005 Apr 7;48(7):2388-406.
REF 30 A highly potent CDK4/6 inhibitor was rationally designed to overcome blood brain barrier in gliobastoma therapy. Eur J Med Chem. 2018 Jan 20;144:1-28.

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