Co-Target(s) Information
Target General Information | Top | ||||
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Target ID | T26623 | Target Info | |||
Target Name | Aldose reductase (AKR1B1) | ||||
Synonyms |
Aldehyde reductase; AKR1B1
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Target Type | Successful Target | ||||
Gene Name | AKR1B1 | ||||
Biochemical Class | Short-chain dehydrogenases reductase | ||||
UniProt ID |
Co-Targets of This Target | Top | |||||
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Co-Target Name | Carbonic anhydrase XII (CA-XII) | Successful Target | ||||
UniProt ID | CAH12_HUMAN | |||||
Gene Name | CA12 | |||||
Synonyms |
Tumor antigen HOM-RCC-3.1.3; Carbonic anhydrase 12; Carbonate dehydratase XII
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Representative Drug(s) | CONTIGOSIDE B | Drug Info | Ki = 52.1 nM | [1] | ||
Co-Target Name | Carbonic anhydrase IV (CA-IV) | Successful Target | ||||
UniProt ID | CAH4_HUMAN | |||||
Gene Name | CA4 | |||||
Synonyms |
Carbonic anhydrase 4; Carbonate dehydratase IV; CAIV
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Representative Drug(s) | CONTIGOSIDE B | Drug Info | Ki = 75.7 nM | [1] | ||
Co-Target Name | Strychnine-binding glycine receptor (GLRA1) | Successful Target | ||||
UniProt ID | GLRA1_HUMAN | |||||
Gene Name | GLRA1 | |||||
Synonyms |
Strychnine-insensitive glycine receptor; Strychnine binding subunit; Glycine receptor 48 kDa subunit; GLRA1
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Representative Drug(s) | Sulindac | Drug Info | EC50 = 380 nM | [2] | ||
Co-Target Name | Carbonic anhydrase II (CA-II) | Successful Target | ||||
UniProt ID | CAH2_HUMAN | |||||
Gene Name | CA2 | |||||
Synonyms |
Carbonic anhydrase C; Carbonic anhydrase 2; Carbonate dehydratase II; CAC
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Representative Drug(s) | CONTIGOSIDE B | Drug Info | Ki = 410 nM | [1] | ||
Co-Target Name | Lysine-specific histone demethylase 1 (LSD) | Clinical trial Target | ||||
UniProt ID | KDM1A_HUMAN | |||||
Gene Name | KDM1A | |||||
Synonyms |
Lysine-specific histone demethylase 1A; LSD1; KIAA0601; KDM1; Flavin-containing amine oxidase domain-containing protein 2; BRAF35-HDAC complex protein BHC110; AOF2
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Representative Drug(s) | CONTIGOSIDE B | Drug Info | IC50 = 950 nM | [3] | ||
Co-Target Name | Carbonic anhydrase VII (CA-VII) | Patented-recorded Target | ||||
UniProt ID | CAH7_HUMAN | |||||
Gene Name | CA7 | |||||
Synonyms |
Carbonic anhydrase 7; Carbonate dehydratase VII
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Representative Drug(s) | CONTIGOSIDE B | Drug Info | Ki = 3.8 nM | [1] | ||
Co-Target Name | Aldo-keto reductase family 1 member B10 (AKR1B10) | Co-Target | ||||
UniProt ID | AK1BA_HUMAN | |||||
Gene Name | AKR1B10 | |||||
Synonyms |
ARL-1; Aldose reductase-like; Aldose reductase-related protein; ARP; hARP; Small intestine reductase; SI reductase
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Representative Drug(s) | SSR-125047 | Drug Info | IC50 = 11.6 nM | Click to Show More | [4] | |
2 | Epalrestat | Drug Info | IC50 = 330 nM | [5] | ||
Co-Target Name | Aldo-keto reductase family 1 member A1 (AKR1A1) | Co-Target | ||||
UniProt ID | AK1A1_HUMAN | |||||
Gene Name | AKR1A1 | |||||
Synonyms |
Alcohol dehydrogenase [NADP(+)]; Aldehyde reductase; Glucuronate reductase; Glucuronolactone reductase
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Representative Drug(s) | SSR-125047 | Drug Info | IC50 = 720 nM | [5] |
References | Top | ||||
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REF 1 | New natural product carbonic anhydrase inhibitors incorporating phenol moieties. Bioorg Med Chem. 2015 Nov 15;23(22):7219-25. | ||||
REF 2 | Ensemble-based virtual screening for cannabinoid-like potentiators of the human glycine receptor alpha1 for the treatment of pain. J Med Chem. 2015 Apr 9;58(7):2958-66. | ||||
REF 3 | Flavone-based natural product agents as new lysine-specific demethylase 1 inhibitors exhibiting cytotoxicity against breast cancer cells in vitro. Bioorg Med Chem. 2019 Jan 15;27(2):370-374. | ||||
REF 4 | Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10. Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20764-9. | ||||
REF 5 | Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10. Bioorg Med Chem. 2010 Apr 1;18(7):2485-90. |
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