Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T31230 Target Info
Target Name Bacterial Fumarate reductase flavoprotein (Bact frdA)
Synonyms
Fumarate reductase; FRDA
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Target Type Successful Target
Gene Name Bact frdA
Biochemical Class CH-CH donor oxidoreductase
UniProt ID
FRDA_HELPY
Co-Targets of This Target  Top
Co-Target Name Bacterial Methionine aminopeptidase (Bact map) Co-Target
UniProt ID MAP1_ECOLI
Gene Name Bact map
Synonyms
Bact MAP; Bact MetAP
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Representative Drug(s) Thiabendazole Drug Info IC50 = 472 nM [1]
Co-Target Name Cytochrome P450 1A2 (CYP1A2) Co-Target
UniProt ID CP1A2_HUMAN
Gene Name CYP1A2
Synonyms
Cholesterol 25-hydroxylase; Hydroperoxy icosatetraenoate dehydratase; CYPIA2; Cytochrome P(3)450; Cytochrome P450 4; Cytochrome P450-P3
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Representative Drug(s) Thiabendazole Drug Info IC50 = 800 nM [2]
References  Top
REF 1 Metal-mediated inhibition of Escherichia coli methionine aminopeptidase: structure-activity relationships and development of a novel scoring function for metal-ligand interactions. J Med Chem. 2006 Jan 26;49(2):511-22.
REF 2 DrugMatrix in vitro pharmacology data. National Toxicology Program

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