Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T31514 Target Info
Target Name Lysosomal alpha-glucosidase (GAA)
Synonyms
GAA; Aglucosidase alfa; Acid maltase
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Target Type Successful Target
Gene Name GAA
Biochemical Class Glycosylase
UniProt ID
LYAG_HUMAN
Co-Targets of This Target  Top
Co-Target Name Intestinal maltase-glucoamylase (MGAM) Successful Target
UniProt ID MGA_HUMAN
Gene Name MGAM
Synonyms
MGAM
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Representative Drug(s) Deoxynojirimycin Drug Info IC50 = 40 nM Click to Show More [1]
2 SALACINOL Drug Info Ki = 1000 nM [2]
Co-Target Name Neutral alpha-glucosidase AB (GANAB) Co-Target
UniProt ID GANAB_HUMAN
Gene Name GANAB
Synonyms
Glucosidase II subunit alpha; Alpha-glucosidase 2
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Representative Drug(s) Deoxynojirimycin Drug Info Ki = 14 nM [3]
References  Top
REF 1 Biological properties of D- and L-1-deoxyazasugars. J Med Chem. 2005 Mar 24;48(6):2036-44.
REF 2 Probing the active-site requirements of human intestinal N-terminal maltase-glucoamylase: Synthesis and enzyme inhibitory activities of a six-membe... Bioorg Med Chem. 2010 Nov 15;18(22):7794-8.
REF 3 Synthesis and biological activity of C-6 modified derivatives of the glucosidase inhibitor 1-deoxynojirimycin. Bioorg. Med. Chem. Lett. 1992;2:27-32.

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