Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T44458 Target Info
Target Name Cyclin-dependent kinase 9 (CDK9)
Synonyms
Tat-associated kinase complex catalytic subunit; TAK; Similar to cyclin-dependent kinase 9; Serine/threonine-protein kinase PITALRE; Cyclin-dependent protein kinase Cdk9; Cell division protein kinase 9; Cell division cycle 2-like protein kinase 4; CDC2L4; CDC2-related kinase; C-2K
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Target Type Clinical trial Target
Gene Name CDK9
Biochemical Class Kinase
UniProt ID
CDK9_HUMAN
Co-Targets of This Target  Top
Co-Target Name Cyclin-dependent kinase 4 (CDK4) Successful Target
UniProt ID CDK4_HUMAN
Gene Name CDK4
Synonyms
PSK-J3; Cell division protein kinase 4
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Representative Drug(s) Flavopiridol Drug Info Ki = 40 nM Click to Show More [1]
2 SNS-032 Drug Info IC50 = 925 nM [4]
Co-Target Name Cyclin-dependent kinase 6 (CDK6) Successful Target
UniProt ID CDK6_HUMAN
Gene Name CDK6
Synonyms
Serine/threonine-protein kinase PLSTIRE; Serine/threonine protein kinase PLSTIRE; Cell division protein kinase 6; CDKN6
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Representative Drug(s) Flavopiridol Drug Info IC50 = 80 nM [2]
Co-Target Name Protein kinase C epsilon (PRKCE) Successful Target
UniProt ID KPCE_HUMAN
Gene Name PRKCE
Synonyms
Protein kinase C epsilon type; PKCE; PKC epsilon; NPKC-epsilon
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Representative Drug(s) Flavopiridol Drug Info IC50 = 480 nM [3]
Co-Target Name Cyclin-dependent kinase 1 (CDK1) Clinical trial Target
UniProt ID CDK1_HUMAN
Gene Name CDK1
Synonyms
P34CDC2; P34 protein kinase; CDKN1; CDC28A; CDC2
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Representative Drug(s) Flavopiridol Drug Info IC50 = 30 nM Click to Show More [5]
2 SNS-032 Drug Info IC50 = 480 nM [4]
Co-Target Name Cyclin-dependent kinase 2 (CDK2) Clinical trial Target
UniProt ID CDK2_HUMAN
Gene Name CDK2
Synonyms
Sin3 associated polypeptide; SIN3-associated protein; P33 protein kinase; Cell division protein kinase 2; CDKN2
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Representative Drug(s) SNS-032 Drug Info IC50 = 38 nM Click to Show More [6]
2 Flavopiridol Drug Info IC50 = 40 nM [7]
Co-Target Name Cyclin-dependent kinase 7 (CDK7) Clinical trial Target
UniProt ID CDK7_HUMAN
Gene Name CDK7
Synonyms
TFIIH basal transcription factor complex kinase subunit; Serine/threonine-protein kinase 1; P39 Mo15; MO15; Cell division protein kinase 7; CDKN7; CDK-activating kinase 1; CDK-activating kinase; CAK1; CAK; 39 kDa protein kinase
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Representative Drug(s) SNS-032 Drug Info IC50 = 62 nM Click to Show More [8]
2 Flavopiridol Drug Info IC50 = 110 nM [8]
Co-Target Name Protein kinase C delta (PRKCD) Clinical trial Target
UniProt ID KPCD_HUMAN
Gene Name PRKCD
Synonyms
nPKC-delta; Tyrosine-protein kinase PRKCD; SDK1; Protein kinase C delta type catalytic subunit; Protein kinase C delta type; PKC-delta
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Representative Drug(s) Flavopiridol Drug Info IC50 = 890 nM [3]
Co-Target Name Cyclin-dependent kinase 5 (CDK5) Patented-recorded Target
UniProt ID CDK5_HUMAN
Gene Name CDK5
Synonyms
Tau protein kinase II catalytic subunit; TPKII catalytic subunit; Serine/threonine-protein kinase PSSALRE; Serine/threonine protein kinase PSSALRE; Proline-directed protein kinase F(A) (PDPK F(A)); Proline-directed protein kinase 33 kDa subunit; PDPK; Cyclin-dependent-like kinase 5; Cyclin-dependent kinase 5 (CDK5); Cell division protein kinase 5; CDKN5
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Representative Drug(s) CYC065 Drug Info IC50 = 23 nM Click to Show More [9]
2 Flavopiridol Drug Info IC50 = 170 nM [8]
Co-Target Name La-related protein 7 (LARP7) Co-Target
UniProt ID LARP7_HUMAN
Gene Name LARP7
Synonyms
La ribonucleoprotein domain family member 7; hLARP7; P-TEFb-interaction protein for 7SK stability; PIP7S
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Representative Drug(s) Flavopiridol Drug Info Ki = 3 nM [1]
Co-Target Name Cyclin dependent kinase 2-Cyclin A2 complex (CDK2-CCNA2) Co-Target
UniProt ID CDK2_HUMAN-CCNA2_HUMAN
Gene Name CDK2-CCNA2
Representative Drug(s) CYC065 Drug Info IC50 = 5 nM Click to Show More [10]
2 SNS-032 Drug Info IC50 = 38 nM [10]
3 Flavopiridol Drug Info IC50 = 100 nM [1]
Co-Target Name Cyclin dependent kinase 2-G1/S specific cyclin E1 complex (CDK2-CCNE1) Co-Target
UniProt ID CDK2_HUMAN-CCNE1_HUMAN
Gene Name CDK2-CCNE1
Representative Drug(s) CYC065 Drug Info IC50 = 5 nM Click to Show More [9]
2 SNS-032 Drug Info IC50 = 38 nM [4]
3 Flavopiridol Drug Info IC50 = 100 nM [1]
Co-Target Name Cyclin dependent kinase 4-G1/S specific cyclin D1 complex (CDK4-CCND1) Co-Target
UniProt ID CDK4_HUMAN-CCND1_HUMAN
Gene Name CDK4-CCND1
Representative Drug(s) Flavopiridol Drug Info IC50 = 20 nM Click to Show More [1]
2 SNS-032 Drug Info IC50 = 925 nM [15]
Co-Target Name Cyclin dependent kinase 5-CDK5 activator 1 complex (CDK5-CDK5R1) Co-Target
UniProt ID CDK5_HUMAN-CD5R1_HUMAN
Gene Name CDK5-CDK5R1
Representative Drug(s) CYC065 Drug Info IC50 = 21 nM Click to Show More [10]
2 Flavopiridol Drug Info IC50 = 60 nM [12]
3 SNS-032 Drug Info IC50 = 340 nM [10]
Co-Target Name Cyclin dependent kinase 1-G2/mitotic specific cyclin B1 complex (CDK1-CCNB1) Co-Target
UniProt ID CDK1_HUMAN-CCNB1_HUMAN
Gene Name CDK1-CCNB1
Representative Drug(s) Flavopiridol Drug Info IC50 = 27 nM Click to Show More [10]
2 SNS-032 Drug Info IC50 = 480 nM [15]
3 CYC065 Drug Info IC50 = 578 nM [10]
Co-Target Name Cyclin dependent kinase 1-G2/mitotic specific cyclin B complex (CDK1-CCNB) Co-Target
UniProt ID CDK1_HUMAN-CCNB1_HUMAN/CCNB2_HUMAN/CCNB3_HUMAN
Gene Name CDK1-CCNB1/CCNB2/CCNB3
Representative Drug(s) Flavopiridol Drug Info IC50 = 30 nM Click to Show More [3]
2 SNS-032 Drug Info IC50 = 480 nM [11]
Co-Target Name Cyclin dependent kinase 2-G1/S specific cyclin E complex (CDK2-CCNE) Co-Target
UniProt ID CDK2_HUMAN-CCNE1_HUMAN/CCNE2_HUMAN
Gene Name CDK2-CCNE1/CCNE2
Representative Drug(s) SNS-032 Drug Info IC50 = 48 nM Click to Show More [11]
2 Flavopiridol Drug Info IC50 = 170 nM [14]
Co-Target Name Cyclin dependent kinase 7-Cyclin H complex (CDK7-CCNH) Co-Target
UniProt ID CDK7_HUMAN-CCNH_HUMAN
Gene Name CDK7-CCNH
Representative Drug(s) SNS-032 Drug Info IC50 = 62 nM Click to Show More [6]
2 Flavopiridol Drug Info IC50 = 110 nM [1]
3 CYC065 Drug Info IC50 = 193 nM [10]
Co-Target Name CDK7-Cyclin H-CDK activating kinase assembly factor MAT1 complex (CDK7-CCNH-MNAT1) Co-Target
UniProt ID CDK7_HUMAN-CCNH_HUMAN-MAT1_HUMAN
Gene Name CDK7-CCNH-MNAT1
Representative Drug(s) SNS-032 Drug Info IC50 = 62 nM Click to Show More [10]
2 Flavopiridol Drug Info IC50 = 514 nM [10]
Co-Target Name Cyclin dependent kinase 2-Cyclin A complex (CDK2-CCNA2) Co-Target
UniProt ID CDK2_HUMAN-CCNA1_HUMAN/CCNA2_HUMAN
Gene Name CDK2-CCNA1/CCNA2
Representative Drug(s) Flavopiridol Drug Info IC50 = 70 nM [13]
Co-Target Name Cyclin dependent kinase 4-G1/S specific cyclin D complex (CDK4-CCND) Co-Target
UniProt ID CDK4_HUMAN-CCND1_HUMAN/CCND2_HUMAN/CCND3_HUMAN
Gene Name CDK4-CCND1-CCND2/CCND3
Representative Drug(s) Flavopiridol Drug Info IC50 = 100 nM Click to Show More [14]
2 SNS-032 Drug Info IC50 = 925 nM [11]
Co-Target Name Cyclin dependent kinase 4-G1/S specific cyclin E1 (CDK4-CCNE1) Co-Target
UniProt ID CDK4_HUMAN-CCNE1_HUMAN
Gene Name CDK4-CCNE1
Representative Drug(s) CYC065 Drug Info IC50 = 232 nM [10]
Co-Target Name Cyclin dependent kinase 6-G1/S specific cyclin D3 complex (CDK6-CCND2) Co-Target
UniProt ID CDK6_HUMAN-CCND3_HUMAN
Gene Name CDK6-CCND3
Representative Drug(s) Flavopiridol Drug Info IC50 = 395 nM [10]
References  Top
REF 1 A review on flavones targeting serine/threonine protein kinases for potential anticancer drugs. Bioorg Med Chem. 2019 Mar 1;27(5):677-685.
REF 2 Molecular docking study on anticancer activity of plant-derived natural products. Med Chem Res. 2009 Jul 28;19:817-35.
REF 3 Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities. J Med Chem. 2002 Aug 29;45(18):3905-27.
REF 4 Cyclin-Dependent Kinase 2 Inhibitors in Cancer Therapy: An Update. J Med Chem. 2019 May 9;62(9):4233-4251.
REF 5 Third-generation CDK inhibitors: A review on the synthesis and binding modes of Palbociclib, Ribociclib and Abemaciclib. Eur J Med Chem. 2019 Jun 15;172:143-153.
REF 6 A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties. Bioorg Med Chem Lett. 2008 Nov 1;18(21):5763-5.
REF 7 A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. Nat Chem Biol. 2008 Jun;4(6):357-65.
REF 8 Recent advances in the development of cyclin-dependent kinase 7 inhibitors. Eur J Med Chem. 2019 Dec 1;183:111641.
REF 9 Cyclin dependent kinase (CDK) inhibitors as anticancer drugs: Recent advances (2015-2019). Bioorg Med Chem Lett. 2019 Oct 15;29(20):126637.
REF 10 Cyclin Dependent Kinase 9 Inhibitors for Cancer Therapy. J Med Chem. 2016 Oct 13;59(19):8667-84.
REF 11 N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent. J Med Chem. 2004 Mar 25;47(7):1719-28.
REF 12 Synthesis, biological evaluation, and molecular modeling of natural and unnatural flavonoidal alkaloids, inhibitors of kinases. J Med Chem. 2012 Mar 22;55(6):2811-9.
REF 13 Thio- and oxoflavopiridols, cyclin-dependent kinase 1-selective inhibitors: synthesis and biological effects. J Med Chem. 2000 Nov 2;43(22):4126-34.
REF 14 Synthesis and biological activity of N-aryl-2-aminothiazoles: potent pan inhibitors of cyclin-dependent kinases. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2973-7.
REF 15 Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5). J Med Chem. 2014 Feb 13;57(3):578-99.

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