Co-Target(s) Information
Target General Information | Top | ||||
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Target ID | T53389 | Target Info | |||
Target Name | TGF-beta receptor type I (TGFBR1) | ||||
Synonyms |
Type I TGFbeta receptor kinase; Transforming growth factor-beta receptor type I; TbetaRI; TbetaR-I; TGFR-1; TGF-beta type I receptor; TGF-beta receptor type-1; Serine/threonine-protein kinase receptor R4; SKR4; Activin receptor-like kinase 5; Activin A receptor type II-like protein kinase of 53kD; ALK5; ALK-5
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Target Type | Clinical trial Target | ||||
Gene Name | TGFBR1 | ||||
Biochemical Class | Kinase | ||||
UniProt ID |
Co-Targets of This Target | Top | |||||
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Co-Target Name | Vascular endothelial growth factor receptor 2 (KDR) | Successful Target | ||||
UniProt ID | VGFR2_HUMAN | |||||
Gene Name | KDR | |||||
Synonyms |
VEGFR2; VEGFR-2; VEGF-2 receptor; Protein-tyrosine kinase receptor flk-1; Kinase insert domain receptor; Fetal liver kinase 1; FLK1; FLK-1; CD309
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Representative Drug(s) | TEW-7197 | Drug Info | IC50 = 97 nM | Click to Show More | [1] | |
2 | LY2157299 | Drug Info | IC50 = 442 nM | [1] | ||
Co-Target Name | Stress-activated protein kinase 2a (p38 alpha) | Clinical trial Target | ||||
UniProt ID | MK14_HUMAN | |||||
Gene Name | MAPK14 | |||||
Synonyms |
SAPK2A; P38 mitogen activatedprotein kinase; P38 Mitogen-activatedprotein kinase alpha; Mitogen-activated protein kinase p38 alpha; Mitogen-activated protein kinase 14; MXI2; MAX-interacting protein 2; MAPK 14; MAP kinase p38alpha; MAP kinase p38 alpha; MAP kinase MXI2; MAP kinase 14; Cytokine suppressive anti-inflammatory drug-binding protein; Cytokine suppressive anti-inflammatory drug binding protein; CSPB1; CSBP2; CSBP1; CSBP; CSAID-binding protein; CSAID binding protein; CRK1
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Representative Drug(s) | LY2157299 | Drug Info | IC50 = 405 nM | [2] | ||
Co-Target Name | Activin receptor type IB (ACVR1B) | Patented-recorded Target | ||||
UniProt ID | ACV1B_HUMAN | |||||
Gene Name | ACVR1B | |||||
Synonyms |
Serine/threonine-protein kinase receptor R2; SKR2; Activin receptor-like kinase 4; Activin receptor type-1B; ALK4; ALK-4; ACVRLK4; ACTR-IB
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Representative Drug(s) | TEW-7197 | Drug Info | IC50 = 13 nM | Click to Show More | [1] | |
2 | LY2157299 | Drug Info | IC50 = 199 nM | [1] | ||
Co-Target Name | Serine/threonine-protein kinase RIPK2 (RIPK2) | Co-Target | ||||
UniProt ID | RIPK2_HUMAN | |||||
Gene Name | RIPK2 | |||||
Synonyms |
Receptor-interacting serine/threonine-protein kinase 2; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing IL-1 beta ICE-kinase; RIP-like-interacting CLARP kinase; Receptor-interacting protein 2; RIP-2; Tyrosine-protein kinase RIPK2
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Representative Drug(s) | LY2157299 | Drug Info | IC50 = 44 nM | Click to Show More | [1] | |
2 | TEW-7197 | Drug Info | IC50 = 54 nM | [1] |
References | Top | ||||
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REF 1 | Discovery of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline (EW-7197): a highly potent, selective, and orally bioavailable inhibitor of TGF-beta type I receptor kinase as cancer immunotherapeutic/antifibrotic agent. J Med Chem. 2014 May 22;57(10):4213-38. | ||||
REF 2 | Synthesis and biological evaluation of 5-(fluoro-substituted-6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)imidazoles as inhibitors of transforming growth factor-beta type I receptor kinase. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5228-31. |
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