Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T53904 Target Info
Target Name HIF-prolyl hydroxylase 1 (HPH-1)
Synonyms
Prolyl hydroxylase domain-containing protein 1; PHD1; Hypoxia-inducible factor prolyl hydroxylase 1; HPH-3; HIF-PH1; HIF-PH; Estrogen-induced tag6; Estrogen-induced tag 6; Egl nine homolog 2; EIT6; EIT-6
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Target Type Successful Target
Gene Name EGLN2
Biochemical Class Paired donor oxygen oxidoreductase
UniProt ID
EGLN2_HUMAN
Co-Targets of This Target  Top
Co-Target Name HIF-prolyl hydroxylase 2 (HPH-2) Patented-recorded Target
UniProt ID EGLN1_HUMAN
Gene Name EGLN1
Synonyms
SM-20; Prolyl hydroxylase domain-containing protein 2; PHD2; Hypoxia-inducible factor prolyl hydroxylase 2; HPH-2; HIF-PH2; Egl nine homolog 1; C1orf12
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Representative Drug(s) FG-4592 Drug Info IC50 = 27 nM Click to Show More [1]
2 BAY-85-3934 Drug Info IC50 = 280 nM [2]
Co-Target Name Egl nine homolog 3 (EGLN3) Co-Target
UniProt ID EGLN3_HUMAN
Gene Name EGLN3
Synonyms
Prolyl hydroxylase EGLN3; Prolyl hydroxylase domain-containing protein 3; PHD3; HPH-1; Hypoxia-inducible factor prolyl hydroxylase 3; HIF-PH3; HIF-prolyl hydroxylase 3; HPH-3
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Representative Drug(s) BAY-85-3934 Drug Info IC50 = 450 nM [2]
Co-Target Name Prolyl 3-hydroxylase OGFOD1 (OGFOD1) Co-Target
UniProt ID OGFD1_HUMAN
Gene Name OGFOD1
Synonyms
uS12 prolyl 3-hydroxylase; 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1; Termination and polyadenylation 1 homolog
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Representative Drug(s) FG-4592 Drug Info IC50 < 1000 nM [1]
References  Top
REF 1 Inhibition of a viral prolyl hydroxylase. Bioorg Med Chem. 2019 Jun 15;27(12):2405-2412.
REF 2 Small-molecule inhibitors of HIF-PHD2: a valid strategy to renal anemia treatment in clinical therapy. Medchemcomm. 2016;7:1271-84.

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