Co-Target(s) Information
Target General Information | Top | ||||
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Target ID | T61722 | Target Info | |||
Target Name | Prostaglandin D2 receptor 2 (PTGDR2) | ||||
Synonyms |
PTGDR2; Chemoattractant receptor-homologous molecule expressed on Th2 cells; CD294
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Target Type | Clinical trial Target | ||||
Gene Name | PTGDR2 | ||||
Biochemical Class | GPCR rhodopsin | ||||
UniProt ID |
Co-Targets of This Target | Top | |||||
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Co-Target Name | Thromboxane A2 receptor (TBXA2R) | Successful Target | ||||
UniProt ID | TA2R_HUMAN | |||||
Gene Name | TBXA2R | |||||
Synonyms |
TXA2-R; TXA2 receptor; Prostanoid TP receptor
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Representative Drug(s) | PGF2alpha | Drug Info | IC50 ~ 0.001 nM | Click to Show More | [1] | |
2 | Ramatroban | Drug Info | Ki = 0.58 nM | [2] | ||
3 | LAROPIPRANT | Drug Info | Ki = 2.95 nM | [4] | ||
Co-Target Name | Prostaglandin F2-alpha receptor (PTGFR) | Successful Target | ||||
UniProt ID | PF2R_HUMAN | |||||
Gene Name | PTGFR | |||||
Synonyms |
Prostanoid FP receptor; PGF2-alpha receptor; PGF2 alpha receptor; PGF receptor; FP prostanoid receptor; FP prostaglandin receptor
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Representative Drug(s) | PGF2alpha | Drug Info | IC50 = 2.5 nM | [3] | ||
Co-Target Name | Prostaglandin E2 receptor EP2 (PTGER2) | Successful Target | ||||
UniProt ID | PE2R2_HUMAN | |||||
Gene Name | PTGER2 | |||||
Synonyms |
Prostanoid EP2 receptor; Prostaglandin E2 receptor EP2 subtype; PGE2 receptor EP2 subtype; PGE receptor, EP2 subtype; PGE receptor EP2 subtype; EP2 receptor
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Representative Drug(s) | LAROPIPRANT | Drug Info | Ki = 136 nM | [4] | ||
Co-Target Name | Aldose reductase (AKR1B1) | Successful Target | ||||
UniProt ID | ALDR_HUMAN | |||||
Gene Name | AKR1B1 | |||||
Synonyms |
Aldehyde reductase; AKR1B1
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Representative Drug(s) | AZD1981 | Drug Info | IC50 = 794 nM | [5] | ||
Co-Target Name | Prostaglandin D2 receptor (PTGDR) | Clinical trial Target | ||||
UniProt ID | PD2R_HUMAN | |||||
Gene Name | PTGDR | |||||
Synonyms |
Prostanoid DP receptor; PGD2 receptor; PGD receptor
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Representative Drug(s) | LAROPIPRANT | Drug Info | IC50 = 0.09 nM | Click to Show More | [4] | |
2 | AMG 853 | Drug Info | IC50 = 4 nM | [6] | ||
3 | MK-7246 | Drug Info | Ki = 373 nM | [2] | ||
Co-Target Name | Prostaglandin E2 receptor EP3 (PTGER3) | Clinical trial Target | ||||
UniProt ID | PE2R3_HUMAN | |||||
Gene Name | PTGER3 | |||||
Synonyms |
Prostanoid EP3 receptor; Prostaglandin E2 receptor EP3 subtype; PGE2-R; PGE2 receptor EP3 subtype; PGE receptor, EP3 subtype; PGE receptor EP3 subtype
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Representative Drug(s) | PGF2alpha | Drug Info | IC50 = 110 nM | Click to Show More | [1] | |
2 | LAROPIPRANT | Drug Info | Ki = 892 nM | [4] | ||
Co-Target Name | Prostaglandin E2 receptor EP1 (PTGER1) | Clinical trial Target | ||||
UniProt ID | PE2R1_HUMAN | |||||
Gene Name | PTGER1 | |||||
Synonyms |
Prostanoid EP1 receptor; Prostaglandin E2 receptor EP1 subtype; PGE2 receptor EP1 subtype; PGE receptor, EP1 subtype; PGE receptor EP1 subtype; EP1 receptor
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Representative Drug(s) | PGF2alpha | Drug Info | IC50 = 220 nM | [1] |
References | Top | ||||
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REF 1 | Synthesis and biological evaluation of prostaglandin-F alkylphosphinic acid derivatives as bone anabolic agents for the treatment of osteoporosis. J Med Chem. 2001 Nov 22;44(24):4157-69. | ||||
REF 2 | Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases. Bioorg Med Chem Lett. 2011 Jan 1;21(1):288-93. | ||||
REF 3 | Synthesis and in vitro evaluation of human FP-receptor selective prostaglandin analogues. Bioorg Med Chem Lett. 2000 Jul 17;10(14):1519-22. | ||||
REF 4 | Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydroc... J Med Chem. 2007 Feb 22;50(4):794-806. | ||||
REF 5 | Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6288-92. | ||||
REF 6 | Discovery of AMG 853, a CRTH2 and DP Dual Antagonist. ACS Med Chem Lett. 2011 Mar 2;2(5):326-30. |
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