Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T62276 | Target Info | |||
| Target Name | Glutamate receptor ionotropic NMDA 1 (NMDAR1) | ||||
| Synonyms |
NmethylDaspartate receptor subunit NR1; NMDR1; NMD-R1; N-methyl-D-aspartate receptor subunit NR1; Glutamate receptor ionotropic, NMDA 1; Glutamate [NMDA] receptor subunit zeta1; Glutamate [NMDA] receptor subunit zeta-1; GluN1
Click to Show/Hide
|
||||
| Target Type | Successful Target | ||||
| Gene Name | GRIN1 | ||||
| Biochemical Class | Glutamate-gated ion channel | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Glutamate receptor ionotropic NMDA 2B (NMDAR2B) | Successful Target | ||||
| UniProt ID | NMDE2_HUMAN | |||||
| Gene Name | GRIN2B | |||||
| Synonyms |
NR3; NR2B; NMDA receptor subunit 2B; NMDA receptor NR2B; NMDA NR2B receptor; N-methylD-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 3; N-methyl D-aspartate receptor subtype 2B; HNR3; Glutamate receptor ionotropic, NMDA 2B; Glutamate receptor NR2B subunit; Glutamate [NMDA] receptor subunit epsilon-2; GluN2B
Click to Show/Hide
|
|||||
| Representative Drug(s) | ELIPRODIL | Drug Info | Ki = 13 nM | [1] | ||
| Co-Target Name | Glutamate receptor AMPA 2 (GRIA2) | Successful Target | ||||
| UniProt ID | GRIA2_HUMAN | |||||
| Gene Name | GRIA2 | |||||
| Synonyms |
Glutamate receptor ionotropic, AMPA 2; Glutamate receptor 2; GluRK2; GluRB; GluR2; GluR-K2; GluR-B; GluR-2; GluA2; AMPAselective glutamate receptor 2; AMPA-selective glutamate receptor 2
Click to Show/Hide
|
|||||
| Representative Drug(s) | NBQX | Drug Info | Ki = 210 nM | [2] | ||
| Co-Target Name | Glutamate receptor AMPA 4 (GRIA4) | Successful Target | ||||
| UniProt ID | GRIA4_HUMAN | |||||
| Gene Name | GRIA4 | |||||
| Synonyms |
Glutamate receptor ionotropic, AMPA 4; GluRD; GluR4; GluA4; GRIA4; AMPAselective glutamate receptor 4
Click to Show/Hide
|
|||||
| Representative Drug(s) | NBQX | Drug Info | Ki = 600 nM | [3] | ||
| Co-Target Name | Glutamate receptor AMPA 3 (GRIA3) | Successful Target | ||||
| UniProt ID | GRIA3_HUMAN | |||||
| Gene Name | GRIA3 | |||||
| Synonyms |
Glutamate receptor ionotropic, AMPA 3; GluRK3; GluRC; GluR3; GluA3; GRIA3; AMPAselective glutamate receptor 3
Click to Show/Hide
|
|||||
| Representative Drug(s) | NBQX | Drug Info | Ki = 900 nM | [3] | ||
| Co-Target Name | Glutamate receptor ionotropic (GRI) | Clinical trial Target | ||||
| UniProt ID | GRIA1_HUMAN; GRIA2_HUMAN; GRIA3_HUMAN; GRIA4_HUMAN | |||||
| Gene Name | NO-GeName | |||||
| Representative Drug(s) | NBQX | Drug Info | IC50 = 52 nM | [4] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Benzo[7]annulene-based GluN2B selective NMDA receptor antagonists: Surprising effect of a nitro group in 2-position. Bioorg Med Chem Lett. 2015 Dec 15;25(24):5748-51. | ||||
| REF 2 | Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain. J Med Chem. 2005 Jun 30;48(13):4200-3. | ||||
| REF 3 | Ethyl (3S,4aR,6S,8aR)-6-(4-ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso-quinoline-3-carboxylic ester: a prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine. J Med Chem. 2002 Sep 26;45(20):4383-6. | ||||
| REF 4 | Homology modeling of the ampa receptor: A quantitative predictive tool for the design of novel antagonists. Bioorg Med Chem Lett. 1997 Jun 3;7(11):1437-42. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.