Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T69494 Target Info
Target Name N-methyl-D-aspartate receptor (NMDAR)
Synonyms
NMDA-R
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Target Type Successful Target
Gene Name NO-GeName
UniProt ID
NOUNIPROTAC
Co-Targets of This Target  Top
Co-Target Name Opioid receptor mu (MOP) Successful Target
UniProt ID OPRM_HUMAN
Gene Name OPRM1
Synonyms
hMOP; Mu-type opioid receptor; Mu opioid receptor; Mu opiate receptor; MOR1A; MOR1; MOR-1; M-OR-1
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Representative Drug(s) Levorphanol Drug Info IC50 = 0.13 nM [1]
Co-Target Name Cannabinoid receptor 2 (CB2) Successful Target
UniProt ID CNR2_HUMAN
Gene Name CNR2
Synonyms
hCB2; Cannabinoid CB2 receptor; CX5; CB2B; CB2A; CB-2
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Representative Drug(s) Dexanabinol Drug Info Ki = 0.15 nM [2]
Co-Target Name Cannabinoid receptor 1 (CB1) Successful Target
UniProt ID CNR1_HUMAN
Gene Name CNR1
Synonyms
Cannabinoid CB1 receptor; CNR; CB-R; CANN6
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Representative Drug(s) Dexanabinol Drug Info EC50 = 0.6 nM [3]
Co-Target Name Opioid receptor kappa (OPRK1) Successful Target
UniProt ID OPRK_HUMAN
Gene Name OPRK1
Synonyms
OPRK; Kappa-type opioid receptor; Kappa opioid receptor; KOR-1; KOR; K-OR-1
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Representative Drug(s) Levorphanol Drug Info Ki = 2.3 nM [4]
Co-Target Name Opioid receptor delta (OPRD1) Successful Target
UniProt ID OPRD_HUMAN
Gene Name OPRD1
Synonyms
OPRD; Delta-type opioid receptor; Delta opioid receptor; DOR-1; D-OR-1
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Representative Drug(s) Levorphanol Drug Info IC50 = 2.9 nM [5]
Co-Target Name Acetylcholinesterase (AChE) Successful Target
UniProt ID ACES_HUMAN
Gene Name ACHE
Synonyms
YT; N-ACHE; ARACHE
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Representative Drug(s) Huperzine A Drug Info IC50 = 33 nM [6]
Co-Target Name Glutamate receptor ionotropic kainate 1 (GRIK1) Successful Target
UniProt ID GRIK1_HUMAN
Gene Name GRIK1
Synonyms
Glutamate receptor 5; GluR5 kainate receptor; GluR5; GluR-5; GRIK1; Excitatory amino acid receptor 3; EAA3
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Representative Drug(s) L-Glutamic Acid Drug Info Ki = 701 nM [7]
Co-Target Name Voltage-gated potassium channel Kv11.1 (KCNH2) Successful Target
UniProt ID KCNH2_HUMAN
Gene Name KCNH2
Synonyms
hERG1; hERG-1; Voltage-gated potassium channel subunit Kv11.1; Potassium voltage-gated channel subfamily H member 2; HERG K+ channel; HERG; H-ERG; Ether-a-go-go-related protein 1; Ether-a-go-go-related gene potassium channel 1; Ether-a-go-go related protein 1; Ether-a-go-go related gene potassium channel 1; Eag related protein 1; Eag homolog; ERG-1; ERG
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Representative Drug(s) Orphenadrine Drug Info IC50 = 851.14 nM [8]
Co-Target Name Glutamate receptor AMPA 4 (GRIA4) Successful Target
UniProt ID GRIA4_HUMAN
Gene Name GRIA4
Synonyms
Glutamate receptor ionotropic, AMPA 4; GluRD; GluR4; GluA4; GRIA4; AMPAselective glutamate receptor 4
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Representative Drug(s) L-Glutamic Acid Drug Info Ki = 868 nM [7]
Co-Target Name Glutamate receptor AMPA 2 (GRIA2) Successful Target
UniProt ID GRIA2_HUMAN
Gene Name GRIA2
Synonyms
Glutamate receptor ionotropic, AMPA 2; Glutamate receptor 2; GluRK2; GluRB; GluR2; GluR-K2; GluR-B; GluR-2; GluA2; AMPAselective glutamate receptor 2; AMPA-selective glutamate receptor 2
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Representative Drug(s) L-Glutamic Acid Drug Info Ki = 940 nM [9]
Co-Target Name Metabotropic glutamate receptor 3 (mGluR3) Clinical trial Target
UniProt ID GRM3_HUMAN
Gene Name GRM3
Synonyms
mGLUR3; Group III metabotropic glutamate receptor; GPRC1C
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Representative Drug(s) L-Glutamic Acid Drug Info Ki = 57.54 nM [10]
Co-Target Name Metabotropic glutamate receptor 2 (mGluR2) Clinical trial Target
UniProt ID GRM2_HUMAN
Gene Name GRM2
Synonyms
mGLUR2; Group II metabotropic glutamate receptor; Glutamate receptor mGLU2; GPRC1B
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Representative Drug(s) L-Glutamic Acid Drug Info EC50 = 290 nM [11]
Co-Target Name Metabotropic glutamate receptor 5 (mGluR5) Clinical trial Target
UniProt ID GRM5_HUMAN
Gene Name GRM5
Synonyms
MGLUR5; GPRC1E
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Representative Drug(s) L-Glutamic Acid Drug Info Ki = 390 nM [12]
Co-Target Name Glutamate receptor ionotropic (GRI) Clinical trial Target
UniProt ID GRIA1_HUMAN; GRIA2_HUMAN; GRIA3_HUMAN; GRIA4_HUMAN
Gene Name NO-GeName
Representative Drug(s) L-Glutamic Acid Drug Info IC50 = 613 nM [13]
Co-Target Name Metabotropic glutamate receptor 1 (mGluR1) Discontinued Target
UniProt ID GRM1_HUMAN
Gene Name GRM1
Synonyms
mGLUR1; Glutamate receptor mGLU1; GPRC1A
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Representative Drug(s) L-Glutamic Acid Drug Info Ki = 250 nM [12]
Co-Target Name Metabotropic glutamate receptor 8 (mGluR8) Literature-reported Target
UniProt ID GRM8_HUMAN
Gene Name GRM8
Synonyms
MGluR8a; MGLUR8; Glutamate receptor mGLU8; GRM8
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Representative Drug(s) L-Glutamic Acid Drug Info IC50 = 5.7 nM [14]
Co-Target Name Excitatory amino acid transporter 3 (SLC1A1) Literature-reported Target
UniProt ID EAA3_HUMAN
Gene Name SLC1A1
Synonyms
Solute carrier family 1 member 1; Sodium-dependent glutamate/aspartate transporter 3; Neuronal and epithelial glutamate transporter; Excitatory amino-acid carrier 1; EAAT3; EAAC1
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Representative Drug(s) L-Glutamic Acid Drug Info Ki = 51 nM [15]
Co-Target Name Glutamate receptor ionotropic kainate 5 (GRIK5) Literature-reported Target
UniProt ID GRIK5_HUMAN
Gene Name GRIK5
Synonyms
KA2; Glutamate receptor ionotropic, kainate 5; Glutamate receptor KA-2; GluK5; GRIK2; Excitatory amino acid receptor 2; EAA2
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Representative Drug(s) L-Glutamic Acid Drug Info Ki = 701 nM [16]
Co-Target Name Glutamate receptor ionotropic kainate 3 (GluK3) Literature-reported Target
UniProt ID GRIK3_HUMAN
Gene Name GRIK3
Synonyms
Glutamate receptor ionotropic, kainate 3; Glutamate receptor 7; GluR7; GluR-7; GluK3; Excitatory amino acid receptor 5; EAA5
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Representative Drug(s) L-Glutamic Acid Drug Info Ki = 789 nM [9]
References  Top
REF 1 The power of visual imagery in drug design. Isopavines as a new class of morphinomimetics and their human opioid receptor binding activity. J Med Chem. 2003 Jan 2;46(1):34-48.
REF 2 Design, synthesis, binding, and molecular modeling studies of new potent ligands of cannabinoid receptors. Bioorg Med Chem. 2007 Aug 15;15(16):5406-16.
REF 3 1-Benzhydryl-3-phenylurea and 1-benzhydryl-3-phenylthiourea derivatives: new templates among the CB1 cannabinoid receptor inverse agonists. J Med Chem. 2005 Nov 17;48(23):7486-90.
REF 4 Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opio... J Med Chem. 2006 Jan 12;49(1):256-62.
REF 5 Synthesis, opioid receptor binding profile, and antinociceptive activity of 1-azaspiro[4.5]decan-10-yl amides. J Med Chem. 1989 Jun;32(6):1259-65.
REF 6 Isoquinoline Alkaloids from Berberis vulgaris as Potential Lead Compounds for the Treatment of Alzheimer's Disease. J Nat Prod. 2019 Feb 22;82(2):239-248.
REF 7 4-Alkyl- and 4-cinnamylglutamic acid analogues are potent GluR5 kainate receptor agonists. J Med Chem. 2000 May 18;43(10):1958-68.
REF 8 Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. Eur J Med Chem. 2011 Feb;46(2):618-30.
REF 9 4-Alkylidenyl glutamic acids, potent and selective GluR5 agonists. Bioorg Med Chem Lett. 2000 Aug 21;10(16):1807-10.
REF 10 A highly selective agonist for the metabotropic glutamate receptor mGluR2. Medchemcomm. 2011;2:1120-4.
REF 11 Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist. J Med Chem. 1998 May 7;41(10):1641-50.
REF 12 Synthesis, molecular modeling studies, and preliminary pharmacological characterization of all possible 2-(2'-sulfonocyclopropyl)glycine stereoisom... J Med Chem. 2007 Sep 20;50(19):4630-41.
REF 13 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacolog... J Med Chem. 2005 Nov 3;48(22):6887-96.
REF 14 (2S,1'S,2'R,3'R)-2(2'-Carboxy-3'-hydroxymethylcyclopropyl)glycine-[3H], a potent and selective radioligand for labeling group 2 and 3 metabotropic ... Bioorg Med Chem Lett. 2005 Jan 17;15(2):349-51.
REF 15 Chemo-enzymatic synthesis of (2S,4R)-2-amino-4-(3-(2,2-diphenylethylamino)-3-oxopropyl)pentanedioic acid: a novel selective inhibitor of human exci... J Med Chem. 2008 Jul 24;51(14):4085-92.
REF 16 Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes. J Med Chem. 1997 Oct 24;40(22):3645-50.

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