Co-Target(s) Information
| Target General Information | Top | ||||
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| Target ID | T69619 | Target Info | |||
| Target Name | Membrane copper amine oxidase (AOC3) | ||||
| Synonyms |
Vascular adhesion protein-1; Vascular adhesion protein 1; VAP1; VAP-1; Semicarbazide-sensitive amine oxidase; SSAO; Membrane primary amine oxidase; HPAO; Copper amine oxidase
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| Target Type | Successful Target | ||||
| Gene Name | AOC3 | ||||
| Biochemical Class | CH-NH(2) donor oxidoreductase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Adrenergic receptor alpha-2A (ADRA2A) | Successful Target | ||||
| UniProt ID | ADA2A_HUMAN | |||||
| Gene Name | ADRA2A | |||||
| Synonyms |
Alpha-2AAR; Alpha-2A adrenoreceptor; Alpha-2A adrenoceptor; Alpha-2A adrenergic receptor; Alpha-2 adrenergic receptor subtype C10; ADRAR; ADRA2R
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| Representative Drug(s) | Clonidine | Drug Info | Ki = 3.8 nM | [1] | ||
| Co-Target Name | Adrenergic receptor Alpha-2 (ADRA2) | Successful Target | ||||
| UniProt ID | ADA2A_HUMAN; ADA2B_HUMAN; ADA2C_HUMAN | |||||
| Gene Name | NO-GeName | |||||
| Synonyms |
Alpha-2 adrenergic receptor; Alpha(2)-adrenoceptor
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| Representative Drug(s) | Clonidine | Drug Info | Ki = 3.8 nM | Click to Show More | [2] | |
| 2 | Clonidine | Drug Info | Ki = 3.8 nM | [2] | ||
| Co-Target Name | Adrenergic receptor alpha-2B (ADRA2B) | Successful Target | ||||
| UniProt ID | ADA2B_HUMAN | |||||
| Gene Name | ADRA2B | |||||
| Synonyms |
Subtype C2; Alpha-2BAR; Alpha-2B adrenoreceptor; Alpha-2B adrenoceptor; Alpha-2B adrenergic receptor; Alpha-2 adrenergic receptor subtype C2; ADRA2RL1; ADRA2L1
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| Representative Drug(s) | Clonidine | Drug Info | Ki = 6.166 nM | [3] | ||
| Co-Target Name | Adrenergic receptor alpha-2C (ADRA2C) | Successful Target | ||||
| UniProt ID | ADA2C_HUMAN | |||||
| Gene Name | ADRA2C | |||||
| Synonyms |
Subtype C4; Alpha-2CAR; Alpha-2C adrenoreceptor; Alpha-2C adrenoceptor; Alpha-2C adrenergic receptor; Alpha-2 adrenergic receptor subtype C4; ADRA2RL2; ADRA2L2
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| Representative Drug(s) | Clonidine | Drug Info | Ki = 9.333 nM | [4] | ||
| Co-Target Name | Monoamine oxidase (MAO) | Successful Target | ||||
| UniProt ID | AOFA_HUMAN; AOFB_HUMAN | |||||
| Gene Name | NO-GeName | |||||
| Synonyms |
Human monoamine oxidase
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| Representative Drug(s) | Clonidine | Drug Info | Ki ~ 100 nM | [5] | ||
| Co-Target Name | Adrenergic receptor alpha-1A (ADRA1A) | Successful Target | ||||
| UniProt ID | ADA1A_HUMAN | |||||
| Gene Name | ADRA1A | |||||
| Synonyms |
Alpha-adrenergic receptor 1c; Alpha-1C adrenergic receptor; Alpha-1A adrenoreceptor; Alpha-1A adrenoceptor; Alpha-1A adrenergic receptor; Alpha adrenergic receptor 1c; Alpha 1A-adrenoreceptor; Alpha 1A-adrenoceptor; ADRA1C
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| Representative Drug(s) | Clonidine | Drug Info | Ki = 512.86 nM | [3] | ||
| Co-Target Name | Myeloperoxidase (MPO) | Clinical trial Target | ||||
| UniProt ID | PERM_HUMAN | |||||
| Gene Name | MPO | |||||
| Synonyms |
MPO
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| Representative Drug(s) | Hydralazine | Drug Info | IC50 = 900 nM | [6] | ||
| Co-Target Name | Imidazoline receptor 1 (IR1) | Literature-reported Target | ||||
| UniProt ID | NISCH_HUMAN | |||||
| Gene Name | NISCH | |||||
| Synonyms |
hIRAS; KIAA0975; Imidazoline-1 receptor candidate protein; Imidazoline-1 receptor; Imidazoline receptor antisera-selected protein; IRAS; IR1; I1R candidate protein; I-1 receptor candidate protein; I-1
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| Representative Drug(s) | Clonidine | Drug Info | Ki = 8.9 nM | [7] | ||
| Co-Target Name | HUAMN alpha-1 adrenergic receptor (ADRA1) | Literature-reported Target | ||||
| UniProt ID | ADA1A_HUMAN; ADA1B_HUMAN; ADA1D_HUMAN | |||||
| Gene Name | ADRA1A; ADRA1B; ADRA1D | |||||
| Synonyms |
Alpha-1 adrenoreceptor
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| Representative Drug(s) | Clonidine | Drug Info | EC50 = 290 nM | [1] | ||
| References | Top | ||||
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| REF 1 | Synthesis and evaluation of 2-[(5-methylbenz-1-ox-4-azin-6-yl)imino]imidazoline, a potent, peripherally acting alpha 2 adrenoceptor agonist. J Med Chem. 1996 Aug 30;39(18):3533-8. | ||||
| REF 2 | Synthesis and biological evaluation of 2-aryliminopyrrolidines as selective ligands for I1 imidazoline receptors: discovery of new sympatho-inhibitory hypotensive agents with potential beneficial effects in metabolic syndrome. J Med Chem. 2015 Jan 22;58(2):878-87. | ||||
| REF 3 | A convenient synthesis of 2-amino-2-oxazolines and their pharmacological evaluation at cloned human alpha adrenergic receptors. Bioorg Med Chem Lett. 1994 Oct 6;4(19):2317-22. | ||||
| REF 4 | Methylation of imidazoline related compounds leads to loss of alpha?-adrenoceptor affinity. Synthesis and biological evaluation of selective I? imidazoline receptor ligands. Bioorg Med Chem. 2012 Aug 1;20(15):4710-5. | ||||
| REF 5 | Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem. 1995 Sep 15;38(19):3681-716. | ||||
| REF 6 | From Dynamic Combinatorial Chemistry to. ACS Med Chem Lett. 2016 Dec 2;8(2):206-10. | ||||
| REF 7 | Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline1 receptor specific agent. J Med Chem. 1996 Mar 15;39(6):1193-5. | ||||
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