Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T82543 Target Info
Target Name Neuronal acetylcholine receptor beta-2 (CHRNB2)
Synonyms
Nicotinic acetylcholine receptor beta2; Nicotinic acetylcholine receptor beta 2-subunit protein; CHRNB2; Beta-2 nAChR; Alpha-4/beta-2 nicotinic receptor
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Target Type Clinical trial Target
Gene Name CHRNB2
Biochemical Class Neurotransmitter receptor
UniProt ID
ACHB2_HUMAN
Co-Targets of This Target  Top
Co-Target Name Neuronal acetylcholine receptor alpha-3/beta-4 (CHRNA3/B4) Successful Target
UniProt ID ACHA3_HUMAN-ACHB4_HUMAN
Gene Name CHRNA3-CHRNB4
Synonyms
Neuronal acetylcholine receptor
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Representative Drug(s) CYTISINE Drug Info Ki = 280 nM [1]
Co-Target Name Acetylcholine receptor alpha-1/beta-1/delta/gamma (CHRNA1/CHRNA1/CHRND/CHRNG) Co-Target
UniProt ID ACHA_HUMAN-ACHB_HUMAN-ACHD_HUMAN-ACHG_HUMAN
Gene Name CHRNA1-CHRNB1-CHRND-CHRNG
Representative Drug(s) CYTISINE Drug Info EC50 = 11 nM [2]
References  Top
REF 1 (+)-Laburnamine, a natural selective ligand and partial agonist for the alpha42 nicotinic receptor subtype. J Nat Prod. 2013 Apr 26;76(4):727-31.
REF 2 Halogenated and isosteric cytisine derivatives with increased affinity and functional activity at nicotinic acetylcholine receptors. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1221-4.

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