Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08XPW
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| Former ID |
DNC005608
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| Drug Name |
CYTISINE
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| Synonyms |
CYTISINE; 485-35-8; Sophorine; Baptitoxine; (-)-Cytisine; Laburnin; Baptitoxin; Tabex; Ulexin; Cytiton; Ulexine; Tsitizin; Cytitone; Cystisine; Cytizin; Citizin; Tabax; (1R,5S)-3,4,5,6-Tetrahydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-8(2H)-one; Baphitoxine; UNII-53S5U404NU; Cytisine (-); HSDB 3560; EINECS 207-616-0; NSC 407282; BRN 0083882; Cytisin; (1r,5s)-1,2,3,4,5,6-Hexahydro-8h-1,5-Methanopyrido[1,2-A][1,5]diazocin-8-One; CHEBI:4055; CHEMBL497939; 53S5U404NU; Cytisine, 98%
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| Drug Type |
Small molecular drug
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| Indication | Tobacco dependence [ICD-11: 6C4A.2; ICD-10: F17.1] | Phase 3 | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C11H14N2O
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| Canonical SMILES |
C1C2CNCC1C3=CC=CC(=O)N3C2
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| InChI |
1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2/t8-,9+/m0/s1
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| InChIKey |
ANJTVLIZGCUXLD-DTWKUNHWSA-N
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| CAS Number |
CAS 485-35-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
589961, 8157380, 10321241, 11112361, 11113087, 11114058, 15899404, 16325148, 22390246, 26752181, 29204005, 29228756, 47434815, 47434816, 48179676, 48253910, 49698590, 49833166, 49960142, 50124228, 56463106, 57326061, 74570465, 76715582, 85148349, 85787849, 88528961, 103654654, 104032478, 104121483, 104253548, 104322739, 104825241, 117673734, 118867704, 121363225, 124757690, 124801290, 124882289, 124882290, 124882291, 125164494, 126594023, 126688798, 134342813, 134975346, 135544049, 136187309, 137248536, 151972521
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| ChEBI ID |
CHEBI:4055
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity. J Med Chem. 2006 May 4;49(9):2673-6. | |||
| REF 3 | Epibatidine isomers and analogues: structure-activity relationships. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5493-7. | |||
| REF 4 | 3,5-Bicyclic aryl piperidines: a novel class of alpha4beta2 neuronal nicotinic receptor partial agonists for smoking cessation. Bioorg Med Chem Lett. 2005 Nov 15;15(22):4889-97. | |||
| REF 5 | Deconstructing cytisine: The syntheses of (+/-)-cyfusine and (+/-)-cyclopropylcyfusine, fused ring analogs of cytisine. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2316-9. | |||
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