Co-Target(s) Information
Target General Information | Top | ||||
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Target ID | T82577 | Target Info | |||
Target Name | Angiotensin-converting enzyme (ACE) | ||||
Synonyms |
Kininase II; Dipeptidyl carboxypeptidase I; DCP1; DCP; CD143 antigen; CD143; ACE
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Target Type | Successful Target | ||||
Gene Name | SLC33A1 | ||||
Biochemical Class | Glycosylase | ||||
UniProt ID |
Co-Targets of This Target | Top | |||||
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Co-Target Name | Angiotensinogenase renin (REN) | Successful Target | ||||
UniProt ID | RENI_HUMAN | |||||
Gene Name | REN | |||||
Synonyms |
Renin; Angiotensinogenase
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Representative Drug(s) | Captopril | Drug Info | Ki = 1.7 nM | [1] | ||
Co-Target Name | Voltage-gated L-type calcium channel (L-CaC) | Successful Target | ||||
UniProt ID | CAC1C_HUMAN; CAC1D_HUMAN; CAC1F_HUMAN; CAC1S_HUMAN | |||||
Gene Name | NO-GeName | |||||
Synonyms |
L-type voltage-dependent Ca(2+) channel; L-type Ca2+ channel; L-type Ca(2+) channel
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Representative Drug(s) | Gallopamil | Drug Info | Ki = 5.4 nM | [2] | ||
Co-Target Name | Voltage-gated calcium channel alpha Cav1.2 (CACNA1C) | Successful Target | ||||
UniProt ID | CAC1C_HUMAN | |||||
Gene Name | CACNA1C | |||||
Synonyms |
Voltage-gated calcium channel subunit alpha Cav1.2; Voltage-dependent L-type calcium channel subunit alpha-1C; Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; CCHL1A1; CACNL1A1; CACN2; CACH2
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Representative Drug(s) | Gallopamil | Drug Info | IC50 = 17 nM | [3] | ||
Co-Target Name | Coagulation factor IIa (F2) | Successful Target | ||||
UniProt ID | THRB_HUMAN | |||||
Gene Name | F2 | |||||
Synonyms |
Prothrombin; Coagulation factor II
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Representative Drug(s) | Captopril | Drug Info | Ki = 48 nM | [4] | ||
Co-Target Name | Carbonic anhydrase XII (CA-XII) | Successful Target | ||||
UniProt ID | CAH12_HUMAN | |||||
Gene Name | CA12 | |||||
Synonyms |
Tumor antigen HOM-RCC-3.1.3; Carbonic anhydrase 12; Carbonate dehydratase XII
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Representative Drug(s) | CONTIGOSIDE B | Drug Info | Ki = 52.1 nM | [5] | ||
Co-Target Name | Leukotriene A-4 hydrolase (LTA4H) | Successful Target | ||||
UniProt ID | LKHA4_HUMAN | |||||
Gene Name | LTA4H | |||||
Synonyms |
Leukotriene A4 hydrolase; Leukotriene A(4)Leukotriene A-4 hydrolase hydrolase; Leukotriene A(4) hydrolase; LTA4; LTA-H; LTA-4hydrolase; LTA-4 hydrolase
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Representative Drug(s) | Captopril | Drug Info | IC50 = 70 nM | [6] | ||
Co-Target Name | Carbonic anhydrase IV (CA-IV) | Successful Target | ||||
UniProt ID | CAH4_HUMAN | |||||
Gene Name | CA4 | |||||
Synonyms |
Carbonic anhydrase 4; Carbonate dehydratase IV; CAIV
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Representative Drug(s) | CONTIGOSIDE B | Drug Info | Ki = 75.7 nM | [5] | ||
Co-Target Name | Human immunodeficiency virus Reverse transcriptase (HIV RT) | Successful Target | ||||
UniProt ID | POL_HV1B1 | |||||
Gene Name | HIV RT | |||||
Synonyms |
HIV p66 RT; HIV Exoribonuclease H
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Representative Drug(s) | Deserpidine | Drug Info | IC50 ~ 200 ug.mL-1 | [7] | ||
Co-Target Name | Carbonic anhydrase II (CA-II) | Successful Target | ||||
UniProt ID | CAH2_HUMAN | |||||
Gene Name | CA2 | |||||
Synonyms |
Carbonic anhydrase C; Carbonic anhydrase 2; Carbonate dehydratase II; CAC
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Representative Drug(s) | Hydrochlorothiazide | Drug Info | Ki = 290 nM | Click to Show More | [8] | |
2 | CONTIGOSIDE B | Drug Info | Ki = 410 nM | [5] | ||
Co-Target Name | Carbonic anhydrase I (CA-I) | Successful Target | ||||
UniProt ID | CAH1_HUMAN | |||||
Gene Name | CA1 | |||||
Synonyms |
Carbonic anhydrase B; Carbonic anhydrase 1; Carbonate dehydratase I; CAB
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Representative Drug(s) | Hydrochlorothiazide | Drug Info | Ki = 328 nM | [9] | ||
Co-Target Name | Lysine-specific histone demethylase 1 (LSD) | Clinical trial Target | ||||
UniProt ID | KDM1A_HUMAN | |||||
Gene Name | KDM1A | |||||
Synonyms |
Lysine-specific histone demethylase 1A; LSD1; KIAA0601; KDM1; Flavin-containing amine oxidase domain-containing protein 2; BRAF35-HDAC complex protein BHC110; AOF2
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Representative Drug(s) | CONTIGOSIDE B | Drug Info | IC50 = 950 nM | [10] | ||
Co-Target Name | Carbonic anhydrase VII (CA-VII) | Patented-recorded Target | ||||
UniProt ID | CAH7_HUMAN | |||||
Gene Name | CA7 | |||||
Synonyms |
Carbonic anhydrase 7; Carbonate dehydratase VII
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Representative Drug(s) | CONTIGOSIDE B | Drug Info | Ki = 3.8 nM | [5] |
References | Top | ||||
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REF 1 | Inhibition of the renin-angiotensin system. A new approach to the therapy of hypertension. J Med Chem. 1981 Apr;24(4):355-61. | ||||
REF 2 | Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds. Eur J Med Chem. 2013 May;63:85-94. | ||||
REF 3 | Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment. J Appl Toxicol. 2012 Oct;32(10):858-66. | ||||
REF 4 | Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3727-31. | ||||
REF 5 | New natural product carbonic anhydrase inhibitors incorporating phenol moieties. Bioorg Med Chem. 2015 Nov 15;23(22):7219-25. | ||||
REF 6 | Probing the inhibition of leukotriene A4 hydrolase based on its aminopeptidase activity. Bioorg Med Chem Lett. 1991;1(10):551-6. | ||||
REF 7 | Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. J Nat Prod. 1991 Jan-Feb;54(1):143-54. | ||||
REF 8 | The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides. Bioorg Med Chem. 2013 Mar 15;21(6):1534-8. | ||||
REF 9 | Sulfonamide inhibition studies of the eta-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum. Bioorg Med Chem. 2015 Feb 1;23(3):526-31. | ||||
REF 10 | Flavone-based natural product agents as new lysine-specific demethylase 1 inhibitors exhibiting cytotoxicity against breast cancer cells in vitro. Bioorg Med Chem. 2019 Jan 15;27(2):370-374. |
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