Co-Target(s) Information
Target General Information | Top | ||||
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Target ID | T84117 | Target Info | |||
Target Name | 5-HT 1E receptor (HTR1E) | ||||
Synonyms |
Serotonin receptor 1E; S31; 5-hydroxytryptamine receptor 1E; 5-HT1E; 5-HT-1E; 5-HT 1E
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Target Type | Successful Target | ||||
Gene Name | HTR1E | ||||
Biochemical Class | GPCR rhodopsin | ||||
UniProt ID |
Co-Targets of This Target | Top | |||||
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Co-Target Name | 5-HT 2C receptor (HTR2C) | Successful Target | ||||
UniProt ID | 5HT2C_HUMAN | |||||
Gene Name | HTR2C | |||||
Synonyms |
Serotonin receptor 2C; HTR1C; 5HT-1C; 5-hydroxytryptamine receptor 2C; 5-hydroxytryptamine receptor 1C; 5-HTR2C; 5-HT2C receptor; 5-HT2C; 5-HT1C; 5-HT-2C; 5-HT-1C
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Representative Drug(s) | Metergolin | Drug Info | Ki = 0.5 nM | [1] | ||
Co-Target Name | 5-HT 1A receptor (HTR1A) | Successful Target | ||||
UniProt ID | 5HT1A_HUMAN | |||||
Gene Name | HTR1A | |||||
Synonyms |
Serotonin receptor 1A; G-21; ADRBRL1; ADRB2RL1; 5-hydroxytryptamine receptor 1A; 5-HT1A receptor; 5-HT1A; 5-HT-1A
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Representative Drug(s) | Metergolin | Drug Info | Ki = 2.3 nM | [2] | ||
Co-Target Name | 5-HT 7 receptor (HTR7) | Clinical trial Target | ||||
UniProt ID | 5HT7R_HUMAN | |||||
Gene Name | HTR7 | |||||
Synonyms |
Serotonin receptor 7; 5HT7; 5-hydroxytryptamine receptor 7; 5-HT7 receptor; 5-HT7; 5-HT-X; 5-HT-7
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Representative Drug(s) | Metergolin | Drug Info | Ki = 6.31 nM | [3] |
References | Top | ||||
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REF 1 | Central serotonin receptors as targets for drug research. J Med Chem. 1987 Jan;30(1):1-12. | ||||
REF 2 | Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells. Bioorg Med Chem Lett. 2013 Mar 15;23(6):1834-8. | ||||
REF 3 | Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives. J Med Chem. 2003 Dec 18;46(26):5638-50. |
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