Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0UA0I
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| Former ID |
DNAP001510
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| Drug Name |
Metergolin
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| Synonyms |
Metergoline; metergoline; Liserdol; 17692-51-2; Methergoline; Metergolina; Metergolinum; Metergolina [DCIT]; Metergolinum [Latin]; Metergolina [Spanish]; Substance 355/255; Metergoline [INN:BAN]; Metergolinum [INN-Latin]; 1-Methyl-N-carbobenzyloxydihydro-D-lysergamin; FI-6337; MLS000069437; UNII-1501393LY5; C25H29N3O2; AHR 3009; 1-Methyl-8-beta-carbobenzyloxyaminomethyl-10-alpha-ergoline; EINECS 241-686-3; 1,6-Dimethyl-8-beta-carbobenzyloxaminomethyl-10-alpha-ergoline; FI 6337; Liserdol (TN)
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| Drug Type |
Small molecular drug
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| Indication | Hyperprolactinaemia [ICD-11: 5A60.1; ICD-10: E22.1; ICD-9: 253.1, 346] | Approved | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C25H29N3O2
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| Canonical SMILES |
CN1CC(CC2C1CC3=CN(C4=CC=CC2=C34)C)CNC(=O)OCC5=CC=CC=C5
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| InChI |
1S/C25H29N3O2/c1-27-14-18(13-26-25(29)30-16-17-7-4-3-5-8-17)11-21-20-9-6-10-22-24(20)19(12-23(21)27)15-28(22)2/h3-10,15,18,21,23H,11-14,16H2,1-2H3,(H,26,29)/t18-,21+,23+/m0/s1
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| InChIKey |
WZHJKEUHNJHDLS-QTGUNEKASA-N
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| CAS Number |
CAS 17692-51-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
855801, 8170546, 10321618, 11466392, 11467512, 11486144, 14781460, 17405287, 22391564, 24263003, 24278105, 26751517, 26751518, 34671115, 46488055, 47721691, 47944884, 47944885, 48170512, 48244474, 48244475, 48319566, 49698459, 49899474, 50104076, 50104077, 50104078, 50558890, 51091556, 53777832, 53790927, 56311628, 56422452, 57310695, 81093356, 85231339, 85788313, 88837624, 90341228, 92125453, 92304154, 93576764, 99445342, 103183978, 103914106, 104171342, 104303418, 117580377, 121361458, 121363124
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| ChEBI ID |
CHEBI:64216
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Odoribacter splanchnicus
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Odoribacter splanchnicus was decreased by Metergoline (adjusted p-values: 2.16E-03). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Roseburia hominis
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia hominis was decreased by Metergoline (adjusted p-values: 2.59E-03). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 3 | Two amino acid differences in the sixth transmembrane domain are partially responsible for the pharmacological differences between the 5-HT1D beta and 5-HT1E 5-hydroxytryptamine receptors. J Neurochem. 1996 Nov;67(5):2096-103. | |||
| REF 4 | Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor. Mol Pharmacol. 1991 Aug;40(2):143-8. | |||
| REF 5 | Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor. Eur J Pharmacol. 2004 Jan 26;484(2-3):127-39. | |||
| REF 6 | Cloning and characterization of the guinea pig 5-HT1F receptor subtype: a comparison of the pharmacological profile to the human species homolog. Neuropharmacology. 1997 Apr-May;36(4-5):569-76. | |||
| REF 7 | Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23. | |||
| REF 8 | Cloning and characterisation of the human 5-HT5A serotonin receptor. FEBS Lett. 1994 Dec 5;355(3):242-6. | |||
| REF 9 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 10 | Endocrine profile and therapeutic employment of a new prolactin-lowering drug, metergoline. Gynecol Obstet Invest. 1980;11(1):1-16. | |||
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