Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T87325 Target Info
Target Name COVID-19 papain-like proteinase (PL-PRO)
Synonyms
COVID-19 papain-like proteinase; COVID-19 PL2-PRO; COVID-19 PL-PRO; COVID-19 main proteinase; COVID-19 non-structural protein 3
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Gene Name COVID-19 rep; COVID-19 1a-1b
Biochemical Class Coronaviruses polyprotein 1ab family
UniProt ID
R1AB_SARS2 (819 - 2763)
Co-Targets of This Target  Top
Co-Target Name Insulin-degrading enzyme (IDE) Successful Target
UniProt ID IDE_HUMAN
Gene Name IDE
Synonyms
Insulysin; Insulinase; Insulin protease; Abeta-degrading protease
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Representative Drug(s) SPI-1005 Drug Info IC50 = 14 nM [1]
Co-Target Name Indoleamine 2,3-dioxygenase 1 (IDO1) Successful Target
UniProt ID I23O1_HUMAN
Gene Name IDO1
Synonyms
Indoleamine-pyrrole 2,3-dioxygenase; INDO; IDO-1; IDO
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Representative Drug(s) SPI-1005 Drug Info Ki = 94 nM [2]
Co-Target Name Soluble epoxide hydrolase (EPHX2) Clinical trial Target
UniProt ID HYES_HUMAN
Gene Name EPHX2
Synonyms
Bifunctional epoxide hydrolase 2
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Representative Drug(s) SPI-1005 Drug Info IC50 = 110 nM [3]
Co-Target Name Lysyl oxidase homolog 2 (LOXL2) Clinical trial Target
UniProt ID LOXL2_HUMAN
Gene Name LOXL2
Synonyms
Lysyl oxidaserelated protein WS914; Lysyl oxidaserelated protein 2; Lysyl oxidaselike protein 2; LOXL2
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Representative Drug(s) Disulfiram Drug Info IC50 = 150 nM [4]
Co-Target Name Monoglyceride lipase (MAGL) Clinical trial Target
UniProt ID MGLL_HUMAN
Gene Name MGLL
Synonyms
Monoacylglycerol lipase; MGL; Lysophospholipaselike; Lysophospholipase-like; Lysophospholipase homolog; HUK5; HU-K5
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Representative Drug(s) Disulfiram Drug Info IC50 = 360 nM [5]
Co-Target Name Macrophage migration inhibitory factor (MIF) Clinical trial Target
UniProt ID MIF_HUMAN
Gene Name MIF
Synonyms
Phenylpyruvate tautomerase; MMIF; L-dopachrome tautomerase; L-dopachrome isomerase; Glycosylation-inhibiting factor; GLIF; GIF
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Representative Drug(s) SPI-1005 Drug Info Ki = 570 nM [6]
Co-Target Name UDP-glucose 4-epimerase (GALE) Literature-reported Target
UniProt ID GALE_HUMAN
Gene Name GALE
Synonyms
UDP-galactose4-epimerase; UDP-galactose4'-epimerase; UDP-galactose 4-epimerase; UDP-N-acetylglucosamine 4-epimerase; UDP-N-acetylgalactosamine 4-epimerase; UDP-GlcNAc 4-epimerase; UDP-GalNAc 4-epimerase; Galactowaldenase
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Representative Drug(s) SPI-1005 Drug Info IC50 = 14 nM [7]
Co-Target Name Lysyl oxidase (LOX) Literature-reported Target
UniProt ID LYOX_HUMAN
Gene Name LOX
Synonyms
Protein-lysine 6-oxidase
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Representative Drug(s) Disulfiram Drug Info IC50 = 320 nM [4]
Co-Target Name Histone-lysine N-methyltransferase EHMT2 (EHMT2) Literature-reported Target
UniProt ID EHMT2_HUMAN
Gene Name EHMT2
Synonyms
Protein G9a; NG36; Lysine N-methyltransferase 1C; KMT1C; Histone H3-K9 methyltransferase 3; HLA-B-associated transcript 8; H3-K9-HMTase 3; G9A; Euchromatic histone-lysine N-methyltransferase 2; C6orf30; BAT8
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Representative Drug(s) SPI-1005 Drug Info IC50 = 400 nM Click to Show More [8]
2 Disulfiram Drug Info IC50 = 600 nM [8]
Co-Target Name Euchromatic histone-lysine N-methyltransferase 1 (EHMT1) Literature-reported Target
UniProt ID EHMT1_HUMAN
Gene Name EHMT1
Synonyms
EHMT1
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Representative Drug(s) SPI-1005 Drug Info IC50 = 730 nM [8]
Co-Target Name Lysyl oxidase homolog 4 (LOXL4) Co-Target
UniProt ID LOXL4_HUMAN
Gene Name LOXL4
Synonyms
Lysyl oxidase-like protein 4; Lysyl oxidase-related protein C
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Representative Drug(s) Disulfiram Drug Info IC50 = 59 nM [4]
Co-Target Name Lysyl oxidase homolog 3 (LOXL3) Co-Target
UniProt ID LOXL3_HUMAN
Gene Name LOXL3
Synonyms
Lysyl oxidase-like protein 3
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Representative Drug(s) Disulfiram Drug Info IC50 = 93 nM [4]
Co-Target Name Gasdermin-D (GSDMD) Co-Target
UniProt ID GSDMD_HUMAN
Gene Name GSDMD
Synonyms
Gasdermin domain-containing protein 1
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Representative Drug(s) Disulfiram Drug Info IC50 = 400 nM [9]
Co-Target Name Gamma-butyrobetaine dioxygenase (BBOX1) Co-Target
UniProt ID BODG_HUMAN
Gene Name BBOX1
Synonyms
Gamma-butyrobetaine hydroxylase; Gamma-BBH; Gamma-butyrobetaine,2-oxoglutarate dioxygenase
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Representative Drug(s) SPI-1005 Drug Info IC50 = 690 nM [10]
References  Top
REF 1 Identification of ebselen as a potent inhibitor of insulin degrading enzyme by a drug repurposing screening. Eur J Med Chem. 2019 Oct 1;179:557-566.
REF 2 Recent advances in the discovery of indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. Med. Chem. Commun. 2019;10:1740-1754.
REF 3 Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain. J Med Chem. 2019 Sep 26;62(18):8443-8460.
REF 4 Inhibition of the LOX enzyme family members with old and new ligands. Selectivity analysis revisited. Bioorg Med Chem Lett. 2018 Oct 1;28(18):3113-3118.
REF 5 Therapeutic Potential of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and N-Acylethanolamine Acid Amidase Inhibitors. J Med Chem. 2017 Jan 12;60(1):4-46.
REF 6 Advances and Insights for Small Molecule Inhibition of Macrophage Migration Inhibitory Factor. J Med Chem. 2018 Sep 27;61(18):8104-8119.
REF 7 Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5744-7.
REF 8 Inhibition of histone lysine methyltransferases G9a and GLP by ejection of structural Zn(II). Bioorg Med Chem Lett. 2018 Apr 15;28(7):1234-1238.
REF 9 Gasdermin D (GSDMD) as a new target for the treatment of infection. Med. Chem. Commun. 2019;10:660-667.
REF 10 Ejection of structural zinc leads to inhibition of gamma-butyrobetaine hydroxylase. Bioorg Med Chem Lett. 2014 Nov 1;24(21):4954-7.

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